Nicotinamide Riboside Protects Optic Nerve from Degeneration: Preclinical Findings

Synopsis Nicotinamide riboside (NR), a precursor to NAD+, protects optic nerve axons from damage caused by tumor necrosis factor (TNF). In rats, NR reduced axon loss, improved autophagy markers (i...

A New Bioluminescent Probe to Monitor Mitochondrial Health Over Time: Preclinical Findings

SynopsisMitochondrial membrane potential (ΔΨm) is a key indicator of mitochondrial health and is involved in diseases like diabetes, cancer, Alzheimer’s, and Parkinson’s. This study introduces a ne...

Nicotinamide Riboside Protects Against Light-Induced Retinal Degeneration: Preclinical Findings

SynopsisRetinal diseases cause a decline in nicotinamide adenine dinucleotide (NAD+), a vital coenzyme for cellular energy and biosynthesis, which may contribute to retinal damage. This study teste...

Safety Evaluation of Synthetic Nicotinamide Riboside (NR-E) in a 90-Day Oral Toxicity Study: Preclinical Findings

Synopsis Nicotinamide riboside (NR) is a form of vitamin B3 that boosts NAD+ levels and may help counter age-related declines in cellular energy. This study tested the safety of a high-purity, syn...

In Ovo Nicotinamide Riboside Injection Improves Broiler Chicken Muscle Growth: Preclinical Findings

Synopsis This study examined how nicotinamide riboside (NR) affects the development and growth of the pectoralis major muscle (PM) in broiler chickens. Fertilized eggs were injected on day 10 of i...

SARM1 Drives Nerve Damage Following Inflammation and Cell Death Signals: Preclinical Findings

SynopsisNeuroinflammation and a type of cell death called necroptosis play big roles in neurodegenerative diseases, often starting with damage to nerve fibers called axons. SARM1 is a key enzyme th...

Nicotinamide Riboside Protects Against Obesity-Induced Atrial Fibrillation: Preclinical FIndings

Synopsis Aging and obesity increase the risk of atrial fibrillation (AF), a condition where the heart beats irregularly. Nicotinamide phosphoribosyltransferase (Nampt) produces NAD+, which is cruc...

Nicotinamide Riboside Improves Social Behavior and Anxiety in Autism: Preclinical Findings

Synopsis Oxytocin (OT) is essential for social recognition, memory, and emotional behaviors, and it also reduces anxiety, especially during stress. CD38 is an enzyme that produces cyclic ADP-ribos...

Nicotinamide Riboside Improves Ovarian Health and Fertility in Aging: Preclinical Findings

Synopsis As female mice age, their ovaries lose follicles and the quality of eggs declines, partly due to lower levels of NAD+. In this study, supplementing aging mice with nicotinamide riboside (...

Nicotinamide Mononucleotide Improves Blood Vessel Function by Converting to Nicotinamide Riboside: Preclinical Findings

Synopsis Nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) are compounds that help make NAD+, which may protect blood vessels. Researchers studied how NMN and NR affect inflammation...

Nicotinamide Riboside Reverses Age-Related Circadian and Mitochondrial Decline: Preclinical Findings

Synopsis Aging disrupts sleep patterns and circadian rhythms, which are linked to metabolic diseases and lower NAD+ levels. This study shows that supplementing with the NAD+ precursor nicotinamide...

Nicotinamide Riboside Reduces Neuroinflammation in Gulf War Illness: Preclinical Findings

Synopsis Gulf War Illness (GWI) affects about 30% of 1991 Gulf War veterans, causing fatigue, pain, and cognitive issues linked to mitochondrial dysfunction. Researchers found that veterans with G...

Nicotinamide Riboside Partially Protects Neurons from TOP1-Linked Neurodegeneration and Extends Lifespan: Preclinical FIndings

Synopsis Topoisomerase 1 (TOP1) helps relieve DNA stress during gene transcription, especially for long genes critical to neuron function. Deleting TOP1 in mouse cortical and hippocampal neurons c...

The Effects of Nutraceutical and Drug Cocktails in Duchenne Muscular Dystrophy: Preclinical Findings

Synopsis Duchenne muscular dystrophy (DMD) causes muscle weakness leading to respiratory failure. Earlier, quercetin showed temporary respiratory benefits in a mouse model. This study tested querc...

Nicotinamide Riboside Protects Against Noise-Induced Hearing Loss: Preclinical Findings

Synopsis Noise exposure can damage hearing by reducing the number of ribbon synapses in the inner ear, which are crucial for transmitting sound signals. In mice, temporary noise exposure caused a ...

NAD+ Precursors Nicotinamide Riboside and Nicotinamide Regulate Cardiac Sodium Channels: Preclinical Findings

Synopsis The heart’s electrical activity depends on sodium channels (NaV1.5) and dysfunction can cause dangerous arrhythmias. Researchers studied how NAD+ precursors nicotinamide riboside (NR) and...

Tracking NAD+ Metabolism in Real Time Using a Genetically Encoded Fluorescent Sensor: Preclinical Findings

Synopsis Tracking NAD+ metabolism in living cells and animals is challenging, but FiNad sensors make it possible. These fluorescent, genetically encoded sensors can detect changes in NAD+ levels i...

Gut Bacteria Support NAD+ Production: Preclinical Findings

Synopsis Nicotinamide adenine dinucleotide (NAD+) is essential for hundreds of cellular processes, including metabolism, DNA repair, and aging. How environmental factors affect NAD+ metabolism is ...

Nicotinamide Riboside Improves DNA Repair, Inflammation, and Atherosclerosis: Preclinical Findings

Synopsis Atherosclerosis, the buildup of fatty plaques in arteries, is a leading cause of heart disease. Beyond cholesterol and inflammation, new research shows that DNA damage in blood vessels al...

Activating the NRK Pathway Improves NAD+ Recycling in Muscle Disorders: Preclinical Findings

Synopsis Hexose-6-Phosphate Dehydrogenase (H6PD) produces NADPH inside the endoplasmic/sarcoplasmic reticulum (ER/SR), helping activate glucocorticoid hormones. However, its broader role in mainta...