Article: The Effects of Nutraceutical and Drug Cocktails in Duchenne Muscular Dystrophy: Preclinical Findings

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Cancer Neurological Health Neuropathy Preclinical

The Effects of Nutraceutical and Drug Cocktails in Duchenne Muscular Dystrophy: Preclinical Findings

Synopsis

Duchenne muscular dystrophy (DMD) causes muscle weakness leading to respiratory failure. Earlier, quercetin showed temporary respiratory benefits in a mouse model. This study tested quercetin combined with nicotinamide riboside, lisinopril, and prednisolone over 7 months to achieve lasting effects. However, none of these treatments, alone or combined, improved respiratory or diaphragm muscle function or reduced muscle damage. The diaphragm muscle in diseased mice was weaker and more fibrotic compared to healthy mice, and treatments did not change this. These findings suggest that these compounds are not effective long-term treatments for respiratory problems in DMD.

Journal

Experimental Physiology

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Nicotinamide Riboside Restores NAD+ Levels and Improves Mitochondrial Function in Skeletal Muscle Cells: Preclinical Findings

Synopsis Nicotinamide phosphoribosyltransferase (NAMPT) helps produce NAD+, which is essential for mitochondrial function and energy balance in skeletal muscle cells. Using gene techniques to redu...

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Nicotinamide Riboside Prevents and Reverses Chemotherapy-Induced Peripheral Neuropathy: Preclinical Findings

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