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The Effects of Nutraceutical and Drug Cocktails in Duchenne Muscular Dystrophy: Preclinical Findings
Synopsis
Duchenne muscular dystrophy (DMD) causes muscle weakness leading to respiratory failure. Earlier, quercetin showed temporary respiratory benefits in a mouse model. This study tested quercetin combined with nicotinamide riboside, lisinopril, and prednisolone over 7 months to achieve lasting effects. However, none of these treatments, alone or combined, improved respiratory or diaphragm muscle function or reduced muscle damage. The diaphragm muscle in diseased mice was weaker and more fibrotic compared to healthy mice, and treatments did not change this. These findings suggest that these compounds are not effective long-term treatments for respiratory problems in DMD.
Journal
Experimental Physiology