Nicotinamide Riboside Reduces Brain Inflammation and Improves Cognitive Function in Diabetic Mice: Preclinical Findings

Synopsis This study tested whether nicotinamide riboside (NR) can reduce brain inflammation and improve cognitive function in diabetic mice. Mice with diet- and chemically-induced diabetes were gi...

NAMPT Deficiency in Mouse Liver Cells Shows Minimal Impact on NAD+ and Mitochondrial Health: Preclinical Findings

Synopsis Supplementation with NAD+ precursors such as nicotinamide riboside (NR) has been shown to improve mitochondrial function and prevent liver fat accumulation in high-fat diet (HFD)-fed rode...

Nicotinamide Riboside Protects the Heart from the Cardiotoxic Effects of Doxorubicin, a Chemotherapy Drug: Preclinical Findings

Synopsis Doxorubicin (DOX) is a common chemotherapy drug, but it can seriously damage the heart, partly due to oxidative stress. Normally, heart cells use autophagy to remove damaged components an...

Nicotinamide Riboside Reduces Liver Fibrosis: Preclinical Findings

Synopsis Liver fibrosis is part of the non-alcoholic fatty liver disease (NAFLD) spectrum, which currently has no approved pharmacological treatment. Researchers tested whether nicotinamide ribosi...

NAD-Related Compounds Affect Immune Cell Growth and Inflammatory Response: Preclinical Findings

Synopsis Nicotinamide (NAM), nicotinamide riboside (NR), and 1-methylnicotinamide (MNA) are compounds related to NAD+ that play important roles in cell signaling, including in the immune system. S...

Mild Vitamin B3 Deficiency Changes Gene Activity in White Fat Tissue: Preclinical Findings

Synopsis Mild vitamin B3 (niacin) deficiency is hard to detect. This study compared mice fed a diet without NR (vitamin B3 precursor) to those given recommended B3 levels, both with low tryptophan...

Nicotinamide Riboside Demonstrates Cardioprotective Effects by Boosting Mitochondrial Stress Response: Preclinical Findings

Synopsis The mitochondrial unfolded protein response (UPRmt) helps cells manage misfolded proteins in mitochondria to maintain function. Cardiac mitochondria are essential for contractile function...

Nicotinamide Riboside Protects Against Liver Fibrosis: Preclinical Findings

Synopsis Nicotinamide riboside (NR) boosts NAD+ levels and offers protective effects in various diseases, but its role in liver fibrosis is unclear. This study tested NR’s ability to protect again...

Nicotinamide Riboside Rejuvenates Aging Gut Stem Cells: Preclinical Findings

Synopsis Aging leads to tissue decline partly due to reduced function of adult stem cells. In the intestine, the number and activity of intestinal stem cells (ISCs) decrease with age, while Paneth...

Muscle Loss and Reduced Physical Performance in Emery–Dreifuss Muscular Dystrophy: Preclinical Findings

Synopsis Autosomal Emery–Dreifuss muscular dystrophy (EDMD) is caused by mutations in the lamin A/C gene (LMNA), which encodes nuclear envelope proteins. The disease typically causes muscle wastin...

Nicotinamide Riboside Enhances Blood Stem Cell Recovery and Regeneration: Preclinical Findings

Synopsis Recent studies show that increased mitochondrial activity and impaired stress response harm hematopoietic stem cells (HSCs), reducing their ability to regenerate. This study found that NR...

Nicotinamide Riboside Protects Motor Neurons in ALS: Preclinical Findings

Synopsis Sirtuins (SIRTs) are enzymes that rely on NAD+ and help regulate DNA repair, metabolism, and oxidative stress. Boosting NAD+ levels can activate SIRTs and antioxidant proteins, reducing m...

Measuring NAD+ Levels in Blood, Muscle, and Cerebrospinal Fluid: Preclinical Findings

SynopsisThe balance between NAD+ and NADH is vital for cell health, aging, and disease. However, accurately measuring NAD+ and its related metabolites is difficult because reduced forms like NADH a...

Nicotinamide Riboside Prevents Gut Damage After Ischemia: Preclinical Findings

Synopsis Acute mesenteric ischaemia happens when blood flow to the intestines is blocked, which can cause tissue damage and even gangrene. This condition is rare but can be life-threatening. Besid...

Measurement of NAD+ Precursors, Including Nicotinamide Riboside, in Human Milk: Preclinical Findings

Synopsis B-vitamins are essential for infant growth and metabolism, and vitamin B3 (niacin)—including nicotinamide (NM) and nicotinic acid (NA)—serves as a precursor for the coenzyme NAD+, which i...

Neonatal Resveratrol and Nicotinamide Riboside Supplementation Increase Energy-Burning Fat Development: Preclinical Findings

Synopsis Early nutrition can influence how fat cells develop and function later in life, impacting metabolism and long-term health. This study explored how early-life supplementation with nicotina...

Maternal Nicotinamide Riboside Supplementation Supports Postpartum Recovery and Offspring Brain Health: Preclinical Findings

Synopsis Metabolic stress can disrupt the balance of NAD+ molecules in the body. Nicotinamide riboside (NR) helps restore NAD+ levels and protect against such stress. This study tested whether NAD...

Nicotinamide Riboside Regulates Inflammation and Improves Mitochondrial Function in Liver Cells: Preclinical Findings

Synopsis This study examined the effects of nicotinamide riboside (NR), a vitamin B3 derivative, on liver cells. Mouse hepatocytes were treated with palmitic acid to mimic fat-induced stress, then...

Nicotinamide Riboside Improves Memory and Brain Health in Alzheimer's Disease and Aging: Preclinical Findings

Synopsis Increasing NAD+ levels to repair damaged mitochondria is a promising strategy for treating Alzheimer’s disease (AD) and other forms of dementia. Nicotinamide riboside (NR) is a safe NAD+ ...

Using NMR Spectroscopy to Measure Nicotinamide Riboside and NAD+ Metabolites in Human Cells: Preclinical Findings

Synopsis NAD+ and NADP+ are essential molecules that help cells produce energy and carry out important chemical reactions. They also act as signals and support protein functions like ADP-ribosylat...