Article: NAD+ Precursors Nicotinamide Riboside and Nicotinamide Regulate Cardiac Sodium Channels: Preclinical Findings

PrevNext
Metabolic Health Obesity Preclinical

NAD+ Precursors Nicotinamide Riboside and Nicotinamide Regulate Cardiac Sodium Channels: Preclinical Findings

Synopsis

The heart’s electrical activity depends on sodium channels (NaV1.5) and dysfunction can cause dangerous arrhythmias. Researchers studied how NAD+ precursors nicotinamide riboside (NR) and nicotinamide (NAM) affect NaV1.5 currents in cells and heart tissue. NR increased peak sodium current and reduced harmful late sodium current, improving channel function through multiple mechanisms including Sirtuin 1-dependent deacetylation. NAM had less of an effect. Mice fed NR showed improved cardiac electrical activity. These findings suggest NR could be a new treatment for heart arrhythmias caused by sodium channel defects.

Journal

Journal of Molecular and Cellular Cardiology

Share

Read more

Cellular Health

Tracking NAD+ Metabolism in Real Time Using a Genetically Encoded Fluorescent Sensor: Preclinical Findings

Synopsis Tracking NAD+ metabolism in living cells and animals is challenging, but FiNad sensors make it possible. These fluorescent, genetically encoded sensors can detect changes in NAD+ levels i...

Read more
Preclinical

Nicotinamide Riboside Protects Against Noise-Induced Hearing Loss: Preclinical Findings

Synopsis Noise exposure can damage hearing by reducing the number of ribbon synapses in the inner ear, which are crucial for transmitting sound signals. In mice, temporary noise exposure caused a ...

Read more