Neonatal Nicotinamide Riboside and Resveratrol Epigenetically Program White Fat Browning: Preclinical Findings

Synopsis Giving newborn male mice resveratrol (RSV) or nicotinamide riboside (NR) can “program” their white fat to develop brown fat-like features (WAT browning) and improve metabolism later in li...

Nicotinamide Riboside Increases NAD+ and Protects Neurons in ALS Models: Preclinical Findings

Synopsis Amyotrophic lateral sclerosis (ALS) is a disease where motor neurons progressively die. Astrocytes from ALS models can cause motor neuron death in cell cultures. Boosting NAD+ levels or i...

Nicotinamide Riboside Protects the Brain from Hypertension-Related Small Vessel Damage: Preclinical Findings

Synopsis Hypertension can cause damage to small blood vessels in the brain, leading to memory problems and white matter injury, but treatments are limited. In this study, mice with angiotensin-ind...

Nicotinamide Riboside Prevents Hearing Loss in Cockayne Syndrome: Preclinical Findings

Synopsis Age-related hearing loss (ARHL) is one of the most common disorders affecting elderly individuals. There is an urgent need for effective preventive measures for ARHL because none are curr...

Nicotinamide Riboside Supports Mitochondrial Health and Neurogenesis in ALS: Preclinical Findings

Synopsis Amyotrophic lateral sclerosis (ALS) is a disease where motor neurons progressively degenerate, leading to muscle weakness and paralysis. Declines in NAD+ contribute to mitochondrial dysfu...

Increasing NAD+ with Nicotinamide Riboside Protects Neurons in Spinocerebellar Ataxia Type 7: Preclinical Findings

Synopsis Spinocerebellar ataxia type 7 (SCA7) is a genetic disorder that damages the cerebellum and impairs movement. Researchers found that in SCA7 mice, key genes controlling calcium in cerebell...

Nicotinamide Riboside Protects Against Alcohol-Induced Depression via the Gut-Brain Axis: Preclinical Findings

Synopsis The gut microbiome influences brain health and mood, and nicotinamide riboside (NR) has shown neuroprotective effects. This study tested whether NR could prevent alcohol-induced depressio...

Extracellular NAD+ Broken Down by Human Cells to Maintain Intracellular NAD+ Levels: Preclinical Findings

Synopsis Nicotinamide adenine dinucleotide (NAD+) is vital for cellular energy and signaling, and human cells replenish NAD+ by using extracellular precursors like nicotinamide (NAM), nicotinic ac...

Study of Nicotinamide Riboside's Properties and Degradation Kinetics: Preclinical Findings

Synopsis Nicotinamide riboside (NR), a form of vitamin B3 and a precursor to NAD+, shows promise as a therapeutic compound for aging. However, little is known about its physical and chemical prope...

Nicotinamide Riboside Administration Improves Mitophagy and Slows Aging in Werner Syndrome: Preclinical Findings

Synopsis Werner syndrome (WS) is a premature aging disease caused by mutations in the WRN gene, which affects DNA repair. WS patients show severe metabolic problems, but the causes are not fully c...

Nicotinamide Riboside Increases Platelet NAD+ but Does Not Extend Their Lifespan: Preclinical Findings

Synopsis Nicotinamide riboside (NR), a vitamin B3 derivative and precursor to NAD+, has been shown in many studies to extend the lifespan of cells and tissues by improving energy metabolism and ce...

Electrochemical Behavior of Nicotinamide Riboside Reveals Its Activity in Biological Systems: Preclinical Findings

Synopsis Nicotinamide riboside (NR) is a popular supplement that boosts NAD+, a molecule important for energy metabolism and functions like vision, hearing, and cognition. NAD+ naturally declines ...

Nicotinamide Riboside Helps Protect the Heart by Improving Mitochondrial Function: Preclinical Findings

Synopsis Endothelial-to-mesenchymal transition (EndMT) contributes to heart scarring (cardiac fibrosis), but how it happens and how to treat it is not fully known. Researchers found that a process...

Limited Effects of Quercetin and Nicotinamide Riboside in Duchenne Muscular Dystrophy: Preclinical Findings

Synopsis Duchenne muscular dystrophy causes progressive muscle weakness and damage. Researchers tested quercetin (Q), nicotinamide riboside (NR), lisinopril (Lis), and prednisolone (Pred), alone o...

Effects of High-Dose Nicotinamide Riboside on White Fat Tissue Function and Insulin Sensitivity: Preclinical Findings

Synopsis Nicotinamide riboside (NR) is a vitamin that helps produce NAD+, a key molecule for metabolism. Although reports of negative effects from high doses of NR are rare, this study examined ho...

Nicotinamide Riboside Protects Against Diet-Induced Liver Injury: Preclinical Findings

Synopsis Nicotinamide riboside (NR), a precursor to NAD+, helps prevent metabolic and age-related disorders in mice, but the role of naturally occurring NR metabolism is less understood. Researche...

NAD+ Levels Control Inflammatory Responses in Immune Cells: Preclinical Findings

SynopsisNAD+ is important for cell metabolism and inflammation, but how it affects immune cells is not well understood. This study looked at how changing NAD+ levels using nicotinamide riboside (NR...

Nicotinamide Ribosides Improves Aerobic Performance: Preclinical Findings

Synopsis Nicotinamide riboside (NR) is a form of vitamin B3 that helps increase NAD+ and improve mitochondrial function, but its effect on physical fitness is unclear. In a study with sedentary an...

L-Carnitine and Nicotinamide Riboside Reduce Obesity and Liver Fat: Preclinical Findings

Synopsis Obesity and fat buildup in the liver can lead to non-alcoholic fatty liver disease (NAFLD). This study tested whether L-carnitine (LC) and nicotinamide riboside (NR), which support fat me...

Nicotinamide Riboside Supplementation Reverses Aging-Associated NAFLD: Preclinical Findings

Synopsis Aging increases the risk of non-alcoholic fatty liver disease (NAFLD), but the mechanisms are not fully clear. This study tested whether nicotinamide riboside (NR), a precursor to NAD+, c...