Nicotinamide Riboside Supplementation Improves Post-Ovulatory Oocyte Quality: Preclinical Findings

Synopsis As eggs age after ovulation, their quality declines, reducing the chances of successful fertilization and embryo development during assisted reproductive technology (ART) procedures like ...

Combination of Metabolic Cofactors and Nicotinamide Riboside Reduces Obesity and Insulin Resistance: Preclinical Findings

SynopsisObesity is a global health problem marked by excessive fat that often leads to metabolic issues like insulin resistance, high blood pressure, abnormal cholesterol levels, and metabolic synd...

Autophagy Promotes Cell Survival by Maintaining Stable NAD+ Levels: Preclinical Findings

SynopsisAutophagy is a cellular process that removes damaged parts of the cell and is important for healthy aging. When autophagy is lost, NAD+ levels fall due to increased activity of enzymes that...

Nicotinamide Riboside Enhances Brain Enzymes to Combat Alzheimer’s Pathology: Preclinical Findings

SynopsisSIRT3 is a mitochondrial enzyme that improves cell function. Deleting SIRT3 causes brain mitochondrial problems and worsens Alzheimer's disease (AD) features in mice, including insulin resi...

Nicotinamide Riboside Activates Mitochondrial Stress Response to Protect Against Osteoarthritis: Preclinical Findings

Synopsis The mitochondrial unfolded protein response (UPRmt) is a protective system that helps mitochondria—the cell’s energy centers—function properly when damaged or stressed. Healthy mitochondr...

Nicotinamide Riboside Improves Fat Metabolism in High-Fructose-Fed Mice: Preclinical Findings

Synopsis High fructose intake can disrupt fat metabolism by causing resistance to a hormone called FGF21. In a preclinical study, mice given nicotinamide riboside (NR) alongside a high-fructose di...

Porcine Placental Extract Increases NAD+ and Energy in Human Skin Cells: Preclinical Findings

Synopsis Nicotinamide adenine dinucleotide (NAD+) is an important molecule that helps our cells produce energy. As we age, NAD+ levels naturally decrease in many tissues, which can contribute to a...

Nicotinamide Riboside and Metabolic Cofactors Improve Gut Health in Fatty Liver Disease: Preclinical Findings

SynopsisThe gut barrier controls what passes into the body and protects organs like the liver. An unhealthy diet and lifestyle cause gut microbiome imbalances (dysbiosis) and gut barrier damage, wh...

Tracking Nicotinamide Riboside Uptake in Cancer Cells: Preclinical Findings

Synopsis Researchers developed a bioluminescent probe (BiNR) to visualize how nicotinamide riboside (NR)—a vitamin B3–derived NAD+ booster—is taken up by cells and tissues in real time. This tool ...

Intravenous Nicotinamide Riboside Protects the Heart from Chemotherapy-Induced Damage: Preclinical Findings

Synopsis Doxorubicin, a widely used chemotherapy drug, is effective against many cancers but often causes dose-dependent heart damage, leading to chronic heart failure. This study evaluated the ca...

Comparison of Metformin and Nicotinamide Riboside in Reducing Tissue Aging: Preclinical Findings

SynopsisMetformin (MET) and nicotinamide riboside (NR) both have potential anti-aging effects, but how they work in different tissues isn't fully clear. This study showed that MET and NR reduce sig...

Nicotinamide Riboside Prevents Low Kidney Nephron Numbers Caused by Maternal Protein Restriction: Preclinical Findings

SynopsisBabies born with fewer nephrons (kidney filters), often due to poor maternal nutrition, have higher risk for kidney disease and high blood pressure later. There are no current treatments to...

Blocking PNP Increases Nicotinamide Riboside Effectiveness for NAD+: Preclinical Findings

Synopsis Nicotinamide riboside (NR), a vitamin B3 derivative and precursor to nicotinamide adenine dinucleotide (NAD+), helps boost cellular energy and repair mechanisms. While NR supplementation ...

NAD+ Depletion Triggers SARM1 Activation and Cell Death, Prevented by PARP Inhibitors: Preclinical Findings

SynopsisSarm1 is a protein that drives programmed axon degeneration by breaking down NAD⁺, but its activity is controlled by NAD+ levels. This study found that in cells treated with the mitochondri...

Nicotinamide Riboside Delays Aging in DNA Repair-Deficient Mice: Preclinical Findings

Synopsis Even though cells can repair DNA, damage naturally builds up over time, harming cell function and contributing to aging. Finding ways to prevent DNA damage or improve repair could help ex...

Mitochondrial Targeting Inhibits Breast Cancer Stem Cells: Preclinical Findings

SynopsisMitochondria are vital cell components that generate energy, build essential molecules, and support cell signaling. In cancer, mitochondria often adapt to fuel tumor growth by supplying the...

Nicotinamide Riboside Supports Pancreatic β-Cell Function During Aging and Diet Stress: Preclinical Findings

SynopsisDisturbances in NAD+ metabolism have been linked to many age-related and metabolic diseases like type 2 diabetes. Pancreatic β-cells play a key role in controlling blood sugar, but how NAD+...

Nicotinamide Riboside Restores Exercise Capacity and Mitochondrial Function in Barth Syndrome: Preclinical Findings

SynopsisBarth syndrome, caused by tafazzin mutation, leads to mitochondrial dysfunction and severe exercise intolerance. In a Drosophila model, NR supplementation restored exercise capacity and mit...

Nicotinamide Riboside Restores Gut Microbiota Diversity and Composition in Alzheimer's Disease

SynopsisAlzheimer's disease (AD) is associated with gut microbiota imbalances. In APP/PS1 transgenic AD mice, gut microbiome diversity was reduced and composition altered compared to wild-type mice...

Increasing NAD+ Partially Restores Endothelial Cell Function Under Low Oxygen: Preclinical Findings

Synopsis Healthy endothelial cells (ECs)—which line blood vessels—are essential for forming new blood vessels, a process known as angiogenesis. Under low oxygen (hypoxic) conditions, cells activat...