Nicotinamide Riboside Activates Mitochondrial Stress Response to Protect Against Osteoarthritis: Preclinical Findings

Synopsis

The mitochondrial unfolded protein response (UPRmt) is a protective system that helps mitochondria—the cell’s energy centers—function properly when damaged or stressed. Healthy mitochondria are crucial for cartilage cells, and mitochondrial problems are common in osteoarthritis (OA). In this study, UPR^mt was activated in stressed mouse cartilage cells and in OA mouse models. Boosting UPRmt with nicotinamide riboside (NR) improved mitochondrial function, reduced cartilage cell death, lessened pain, and slowed OA progression. In OA patients, higher UPRmt activity was linked to healthier cartilage, less hip pain, and lower joint inflammation. These findings suggest that enhancing UPRmt with NR could protect cartilage and may offer a new approach to treating OA.

Journal

Experimental & Molecular Medicine