Article: Nicotinamide Riboside Supplementation Improves Post-Ovulatory Oocyte Quality: Preclinical Findings

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Preclinical Reproductive Health

Nicotinamide Riboside Supplementation Improves Post-Ovulatory Oocyte Quality: Preclinical Findings

Synopsis

As eggs age after ovulation, their quality declines, reducing the chances of successful fertilization and embryo development during assisted reproductive technology (ART) procedures like IVF. This study found that nicotinamide riboside (NR), a vitamin B3–derived NAD+ booster, helps preserve the quality of aging oocytes during in vitro culture. In mouse experiments, NAD+ levels naturally decreased in post-ovulatory eggs, leading to mitochondrial dysfunction, oxidative stress (ROS buildup), and DNA damage. Supplementing with NR restored NAD+ levels, maintained healthy chromosome and spindle structure, reduced ROS and apoptosis, and improved early embryonic development. These results suggest that NR supplementation may enhance egg viability and embryo quality, potentially improving the success rate of fertility treatments in women undergoing ART.

Journal

Reproduction

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Metabolic Health

Combination of Metabolic Cofactors and Nicotinamide Riboside Reduces Obesity and Insulin Resistance: Preclinical Findings

SynopsisObesity is a global health problem marked by excessive fat that often leads to metabolic issues like insulin resistance, high blood pressure, abnormal cholesterol levels, and metabolic synd...

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Cellular Health

Mitochondrial PARP1 Regulates Mitochondrial DNA and Aging: Preclinical Findings

Synopsis Scientists have discovered that the enzyme PARP1, known for repairing DNA in the cell nucleus, is also active inside mitochondria, where it helps control mitochondrial DNA (mtDNA). Using ...

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