Resveratrol and Dimethyl Fumarate Combination Therapy Shows Promise in Friedreich’s Ataxia: Preclinical Findings

Synopsis Friedreich’s ataxia (FA) is a rare inherited disorder that affects the nervous system and heart, with no approved therapies yet. Researchers tested eight compounds—including nicotinamide ...

Nicotinamide Riboside and Natural Antioxidants Protect Against Radiation Damage and Improve Survival: Preclinical Findings

Synopsis Researchers tested whether natural compounds could protect against harmful ionizing radiation, which has applications in medicine, space travel, and biotechnology. In mice exposed to leth...

Nicotinamide Riboside Protects Heart Function and Survival After Circadian Disruption: Preclinical Findings

Synopsis The circadian clock, which regulates daily biological rhythms, also plays an important role in heart health. In this study, mice lacking REV-ERB receptors—key circadian regulators in the ...

NAD+ Precursors Restore Mitochondrial Function and Prevent Nerve Damage in Diabetes: Preclinical Findings

SynopsisDiabetic peripheral neuropathy involves nerve degeneration linked to low NAD+ levels. Researchers tested whether NAD+ precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside ...

Nicotinamide Riboside Protects Against Experimental Necrotizing Enterocolitis: Preclinical Findings

Synopsis Necrotizing enterocolitis (NEC) is a life-threatening intestinal disease that affects newborns, often due to oxidative stress and poor blood flow in the gut. This study found that nicotin...

Nicotinamide Riboside Protects Cells From Oxidative Damage: Preclinical Findings

Synopsis Oxidative stress, caused by an overload of reactive oxygen species, can make cells die either by apoptosis (a controlled process) or necrosis (an uncontrolled one). Scientists found that ...

NAD+ Precursors Prevent Allergic Responses by Regulating Immune Function: Preclinical Findings

Synopsis Nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN)—both vitamin B3 derivatives that boost NAD+ levels—may help prevent severe allergic reactions such as anaphylaxis. In this...

Nicotinamide Riboside and NMN Enhance Regeneration of Lung Cells in 3D Culture: Preclinical Findings

Synopsis Type 2 alveolar epithelial cells (AEC2s) are crucial for repairing and regenerating lung tissue after injury. This study found that in both idiopathic pulmonary fibrosis (IPF) patients an...

Nicotinamide Riboside Improves Vascular Health and Reduces Inflammation in Atherosclerosis: Preclinical Findings

Synopsis Atherosclerosis, the buildup of plaques in arteries, begins with endothelial cell dysfunction and inflammation triggered by high cholesterol. This study found that loss of SIRT3, a mitoch...

Effects of Nicotinamide Riboside on Exercise Performance: Preclinical Findings

Synopsis This proof-of-concept study tested whether chronic nicotinamide riboside (NR) supplementation, a precursor of nicotinamide adenine dinucleotide (NAD+), could enhance physical performance ...

Nicotinamide Riboside Restores Mitochondrial Balance and Protects the Diabetic Heart: Preclinical Findings

Synopsis In diabetes, heart damage often occurs because of mitochondrial imbalance, where the cell’s energy-producing structures become fragmented and dysfunctional. This study found that nicotina...

DNA Replication Stress Causes Complex Metabolic Changes: Preclinical Findings

SynopsisDNA replication stress occurs when cells struggle to copy damaged DNA, affecting metabolism. Using mice lacking the DNA polymerase Rev1, researchers observed sex-specific metabolic changes:...

Dihydronicotinamide Riboside Promotes a Pro-Inflammatory Macrophage Phenotype: Preclinical Findings

Synopsis This study explored how various NAD precursors—including nicotinamide riboside (NR), nicotinamide mononucleotide (NMN), nicotinamide (NAM), and a newer compound called NRH—influence the b...

Increasing NAD+ with NR Protects Against Aortic Aneurysms: Preclinical Findings

Synopsis Researchers found that weakened mitochondrial function in blood vessel walls contributes to aortic aneurysms and ruptures, which can cause sudden death. In mice prone to atherosclerosis a...

Selective Mitochondrial Inheritance Links Metabolism to Cell Fate: Preclinical Findings

Synopsis This study discovered that the age of mitochondria—the cell’s energy-producing structures—plays a major role in determining how stem cells divide and develop. In epithelial stem-like cell...

NR and NMN Restore Meibomian Gland Function and Tear Health: Preclinical Findings

Synopsis This study found that increasing NAD+ levels in the eye can help reverse age-related meibomian gland dysfunction, a major cause of dry eye disease in older adults. The meibomian glands, l...

Effects of Intravenous Nicotinamide Riboside on Muscle NAD+: Preclinical Findings

Synopsis Although nicotinamide riboside (NR)—a common NAD+ booster—is believed to enhance energy metabolism, clinical studies have shown little effect on muscle function or insulin sensitivity. To...

Nicotinamide Riboside Reduces Chemotherapy-Induced Eye and Body Hypersensitivity: Preclinical Findings

SynopsisChemotherapy often causes dry eye and nerve pain, which may be due to nerve damage. This study treated rats given the chemotherapy drug paclitaxel with nicotinamide riboside (NR). Paclitaxe...

Nicotinamide Riboside Alters Gut Microbiota to Reduce Weight Gain from High-Fat Diet in Mice: Preclinical Findings

SynopsisThe gut microbiome influences energy balance and obesity risk. Nicotinamide riboside (NR), a vitamin B3 form and NAD+ precursor, can reduce weight gain and increase energy use in obese mice...

Nicotinamide Riboside Suppresses Coronavirus Replication: Preclinical Findings

Synopsis Viruses like SARS-CoV-2, which causes COVID-19, rely on the host’s metabolism to reproduce. This study used a related coronavirus model in mice to explore how metabolic interventions coul...