Article: Nicotinamide Riboside Supplementation Reduces Oxidative Stress and Enhances Mitochondrial Function in Chronic Kidney Disease Immune Cells: Clinical Findings

Jan 23, 2025 Clinical Metabolic Health

Nicotinamide Riboside Supplementation Reduces Oxidative Stress and Enhances Mitochondrial Function in Chronic Kidney Disease Immune Cells: Clinical Findings

Objectives

To investigate the effects of NR and CoQ10 on oxidative stress, inflammation, and mitochondrial function in patients with chronic kidney disease (CKD).

Journal

Clinical Journal of the American Society of Nephrology

Key Outcomes

NR supplementation primarily affected gene activity related to carbohydrate/fat metabolism and immune signaling, while CoQ10 influenced genes linked to immune/stress response and fat metabolism.
Both NR and CoQ10 reduced plasma oxidative stress markers, but their effects on inflammation markers differed. NR showed mixed results, whereas CoQ10 consistently reduced inflammation.
Only NR improved mitochondrial function in monocytes, a type of white blood cell.

Duration

6 weeks

Dose

1000 mg*
*Patients were given NR (1000mg) or CoQ10 (1200 mg).

Study Design

Randomized, double-blind, placebo-controlled, crossover study in 25 chronic kidney disease (CKD) patients

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