Nicotinamide Riboside Supplementation Benefits in Werner's Syndrome: Clinical Findings

Objectives

To evaluate the safety and efficacy of oral NR supplementation in patients with Werner Syndrome (WS).

Journal

Aging Cell

Key Outcomes

• NR improved arterial stiffness, as measured by the cardio-ankle vascular index (CAVI).
• NR increased the number of high-density lipoprotein (HDL) particles.
• NR reduced skin ulcer size and tended to prevent heel pad thinning, while ulcers worsened in the placebo group.

Duration

26 weeks

Dose

1000 mg

Study Design

Randomized, double-blind, placebo-controlled, crossover study in 9 patients with Werner Syndrome