Article: Nicotinamide Riboside Supplementation Benefits in Werner's Syndrome: Clinical Findings

Jun 3, 2025 Clinical Healthy Aging & Longevity Orphan Disease

Nicotinamide Riboside Supplementation Benefits in Werner's Syndrome: Clinical Findings

Objectives

To evaluate the safety and efficacy of oral NR supplementation in patients with Werner Syndrome (WS).

Journal

Aging Cell

Key Outcomes

NR improved arterial stiffness, as measured by the cardio-ankle vascular index (CAVI).
NR increased the number of high-density lipoprotein (HDL) particles.
NR reduced skin ulcer size and tended to prevent heel pad thinning, while ulcers worsened in the placebo group.

Duration

26 weeks

Dose

1000 mg

Study Design

Randomized, double-blind, placebo-controlled, crossover study in 9 patients with Werner Syndrome

See Published Study

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