Role of NAD+ in Aging and Disease: Review

Synopsis

NAD+ is a key coenzyme for many physiological reactions, particularly those supporting mitochondrial function. Its decline with aging contributes to chronic conditions like cognitive decline, muscle loss, and metabolic disease, all of which involve impaired mitochondrial maintenance systems. Raising NAD+ through vitamin B3 precursors or drugs has become a common strategy to restore cellular balance. This review summarizes advances in understanding NAD+ metabolism, its role in mitochondrial health, results from clinical trials of NAD-boosting therapies, and priorities for translating these findings into real-world treatments.

JOURNAL

npj Metabolic Health and Disease

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Cancer

Nicotinamide Riboside Enhances NK Cell Anti-Tumor Activity: Preclinical Findings

Synopsis Tumor-produced lactate weakens natural killer (NK) cells by causing lysine lactylation (Kla), disrupting NAD+ metabolism, and fragmenting mitochondria, which reduces cytotoxicity. Supplem...

Preclinical

Nicotinamide Riboside Protects Against Heat Stress–Induced Testicular Damage and Improves Boar Fertility: Preclinical Findings

Synopsis Heat stress (HS) from rising global temperatures negatively affects male fertility, damaging the testes and reducing semen quality. This study examined how HS alters testicular NAD+ metab...

Role of NAD+ in Aging and Disease: Review

Synopsis

JOURNAL

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