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Nicotinamide Riboside Supplementation Combined with Exercise May Improve Nighttime Blood Pressure and Arterial Stiffness: Clinical Findings
Objectives
To evaluate whether combining aerobic exercise with nicotinamide riboside (NR) could enhance blood pressure (BP) control in sedentary older adults with hypertension.
Journal
GeroScience
Key Outcomes
- NR+Ex was not more effective than exercise alone in lowering blood pressure. It showed a trend toward increased daytime systolic and diastolic BP, whereas the placebo + exercise group showed small reductions.
- NR+Ex trended toward a greater reduction in pulse wave velocity (PWV), suggesting possible improvement in arterial stiffness. In contrast, NR alone trended toward increased PWV.
- Post-hoc analysis showed NR+Ex trended toward greater nighttime reductions in systolic and diastolic BP in participants not on antihypertensive medications.
Duration
6 weeks
Dose
1000 mg
Study Design
Randomized, double-blind, placebo-controlled pilot study in 54 sedentary older adults with hypertension