Nicotinamide Riboside Supplementation Combined with Exercise May Improve Nighttime Blood Pressure and Arterial Stiffness: Clinical Findings

Objectives

To evaluate whether combining aerobic exercise with NR could enhance blood pressure (BP) control in sedentary older adults with hypertension.

Journal

GeroScience

Key Outcomes

• NR+Ex was not more effective than exercise alone in lowering blood pressure. It showed a trend toward increased daytime systolic and diastolic BP, whereas the placebo + exercise group showed small reductions.
• NR+Ex trended toward a greater reduction in pulse wave velocity (PWV), suggesting possible improvement in arterial stiffness. In contrast, NR alone trended toward increased PWV.
• Post-hoc analysis showed NR+Ex trended toward greater nighttime reductions in systolic and diastolic BP in participants not on antihypertensive medications.

Duration

6 weeks

Dose

1000 mg

Study Design

Randomized, double-blind, placebo-controlled pilot study in 54 sedentary older adults with hypertension