Muscle Loss and Reduced Physical Performance in Emery–Dreifuss Muscular Dystrophy: Preclinical Findings

Synopsis Autosomal Emery–Dreifuss muscular dystrophy (EDMD) is caused by mutations in the lamin A/C gene (LMNA), which encodes nuclear envelope proteins. The disease typically causes muscle wastin...

Nicotinamide Riboside Enhances Blood Stem Cell Recovery and Regeneration: Preclinical Findings

Synopsis Recent studies show that increased mitochondrial activity and impaired stress response harm hematopoietic stem cells (HSCs), reducing their ability to regenerate. This study found that NR...

Nicotinamide Riboside Protects Motor Neurons in ALS: Preclinical Findings

Synopsis Sirtuins (SIRTs) are enzymes that rely on NAD+ and help regulate DNA repair, metabolism, and oxidative stress. Boosting NAD+ levels can activate SIRTs and antioxidant proteins, reducing m...

Measuring NAD+ Levels in Blood, Muscle, and Cerebrospinal Fluid: Preclinical Findings

SynopsisThe balance between NAD+ and NADH is vital for cell health, aging, and disease. However, accurately measuring NAD+ and its related metabolites is difficult because reduced forms like NADH a...

Nicotinamide Riboside Prevents Gut Damage After Ischemia: Preclinical Findings

Synopsis Acute mesenteric ischaemia happens when blood flow to the intestines is blocked, which can cause tissue damage and even gangrene. This condition is rare but can be life-threatening. Besid...

Measurement of NAD+ Precursors, Including Nicotinamide Riboside, in Human Milk: Preclinical Findings

Synopsis B-vitamins are essential for infant growth and metabolism, and vitamin B3 (niacin)—including nicotinamide (NM) and nicotinic acid (NA)—serves as a precursor for the coenzyme NAD+, which i...

Neonatal Resveratrol and Nicotinamide Riboside Supplementation Increase Energy-Burning Fat Development: Preclinical Findings

Synopsis Early nutrition can influence how fat cells develop and function later in life, impacting metabolism and long-term health. This study explored how early-life supplementation with nicotina...

Nicotinamide Riboside Improves Redox Balance and Muscle Performance: Clinical Findings

Objectives To investigate the effects of acute NR supplementation on redox homeostasis and exercise performance in young and old humans. Journal European Journal of Nutrition Key Outcomes Within ...

Nicotinamide Riboside and Pterostilbene Slow Disease Progression in ALS Patients: Clinical Findings

Objectives To assess the safety, tolerability, and efficacy of nicotinamide riboside and pterostilbene (NRPT) supplementation in people with amyotrophic lateral sclerosis (ALS). Journal Amyotrophi...

Maternal Nicotinamide Riboside Supplementation Supports Postpartum Recovery and Offspring Brain Health: Preclinical Findings

Synopsis Metabolic stress can disrupt the balance of NAD+ molecules in the body. Nicotinamide riboside (NR) helps restore NAD+ levels and protect against such stress. This study tested whether NAD...

Nicotinamide Riboside Regulates Inflammation and Improves Mitochondrial Function in Liver Cells: Preclinical Findings

Synopsis This study examined the effects of nicotinamide riboside (NR), a vitamin B3 derivative, on liver cells. Mouse hepatocytes were treated with palmitic acid to mimic fat-induced stress, then...

Nicotinamide Riboside Improves Memory and Brain Health in Alzheimer's Disease and Aging: Preclinical Findings

Synopsis Increasing NAD+ levels to repair damaged mitochondria is a promising strategy for treating Alzheimer’s disease (AD) and other forms of dementia. Nicotinamide riboside (NR) is a safe NAD+ ...

Using NMR Spectroscopy to Measure Nicotinamide Riboside and NAD+ Metabolites in Human Cells: Preclinical Findings

Synopsis NAD+ and NADP+ are essential molecules that help cells produce energy and carry out important chemical reactions. They also act as signals and support protein functions like ADP-ribosylat...

Effects of Nicotinamide Riboside Against Kidney Injury: Preclinical Findings

Synopsis Sirtuin 3 (Sirt3) is an important protein that helps regulate energy use and protect cells from stress. Researchers studied its role in contrast-induced acute kidney injury (CIAKI) using ...

Nicotinamide Riboside Restores NAD+ Levels and Improves Heart Function in Cardiomyopathy: Preclinical Findings

Synopsis Cardiomyopathy caused by mutations in the lamin A/C gene (LMNA cardiomyopathy) leads to heart muscle and electrical dysfunction, often resulting in heart failure. Currently, there is no t...

Nicotinamide Riboside Restores Metabolic Balance in Muscle Cells by Reversing NAD+ Depletion: Preclinical Findings

Synopsis Skeletal muscle plays a key role in overall body metabolism, but aging and disease can reduce its ability to function properly. Researchers studied how changes in NAD+ levels affect muscl...

The Effects of NAD+ Boosting in Mitochondrial DNA Depletion Syndrome: Preclinical Findings

Synopsis Patients with mtDNA depletion syndrome 3 (MTDPS3) often die young from liver failure due to severely reduced mitochondrial DNA. Research into treatments has been difficult because MTDPS3 ...

Nicotinamide Riboside Prevents SARM1-Induced NAD+ and ATP Depletion: Preclinical Findings

Synopsis Mitochondrial dysfunction is a key feature of neurodegenerative diseases like Parkinson’s. SARM1 promotes nerve damage by breaking down NAD+, and its activity is increased when phosphoryl...

Nicotinamide and Nicotinamide Riboside Induce Rapid Differentiation and Function in Retinal Pigment Epithelial Cells: Preclinical Findings

Synopsis Human retinal pigment epithelial (RPE) cells, especially the ARPE-19 cell line, are commonly used in eye and general epithelial cell research. While they are convenient and consistent, th...

L-Glutamine and Nicotinamide Riboside Supplementation in Congenital Glutamine Synthetase Deficiency: Case Study

Objectives To assess the clinical and biochemical efficacy of L-glutamine and NR supplementation in a child with congenital GS deficiency. Journal Neuropediatrics Key Outcomes Treatment with L-gl...