The Effects of NAD+ Boosting in Mitochondrial DNA Depletion Syndrome: Preclinical Findings

Synopsis Patients with mtDNA depletion syndrome 3 (MTDPS3) often die young from liver failure due to severely reduced mitochondrial DNA. Research into treatments has been difficult because MTDPS3 ...

Nicotinamide Riboside Prevents SARM1-Induced NAD+ and ATP Depletion: Preclinical Findings

Synopsis Mitochondrial dysfunction is a key feature of neurodegenerative diseases like Parkinson’s. SARM1 promotes nerve damage by breaking down NAD+, and its activity is increased when phosphoryl...

Nicotinamide and Nicotinamide Riboside Induce Rapid Differentiation and Function in Retinal Pigment Epithelial Cells: Preclinical Findings

Synopsis Human retinal pigment epithelial (RPE) cells, especially the ARPE-19 cell line, are commonly used in eye and general epithelial cell research. While they are convenient and consistent, th...

L-Glutamine and Nicotinamide Riboside Supplementation in Congenital Glutamine Synthetase Deficiency: Case Study

Objectives To assess the clinical and biochemical efficacy of L-glutamine and NR supplementation in a child with congenital GS deficiency. Journal Neuropediatrics Key Outcomes Treatment with L-gl...

Preventing NMN Accumulation Protects Nerves from Chemotherapy-Induced Damage: Preclinical Findings

Synopsis Axon degeneration is a key feature of chemotherapy-induced peripheral neuropathy (CIPN). While it has been linked to loss of NAD+ via SARM1, recent evidence suggests that a buildup of NMN...

Nicotinamide Riboside Increases Heat Production in Lean Mice: Preclinical Findings

Synopsis Nicotinamide Riboside (NR) is a NAD+ booster with wide physiological repercussion including the improvement on glucose and lipid balance, increasing the life expectancy in mammals. Howeve...

Early-Life Nicotinamide Riboside and Resveratrol Supplementation Improves Long-Term Metabolic Health: Preclinical Findings

Synopsis This study explores how early-life nutritional supplementation with resveratrol (RSV) and nicotinamide riboside (NR)—both compounds known for their anti-obesity and metabolic-enhancing ef...

Effects of Nicotinamide Riboside on Energy Metabolism and Exercise Performance: Preclinical Findings

Synopsis Nicotinamide riboside (NR) is a form of vitamin B3 that can boost NAD(P) levels, which are important for energy metabolism in cells. While previous studies in older or sick mice showed th...

High-Dose Nicotinamide Riboside Supplementation Is Safe and Effective: Clinical Findings

Objectives To test the safety of NR supplementation and its potential to improve insulin sensitivity and other metabolic parameters in obese, insulin-resistant men. Journal The American Journal of...

Mitochondria Can Directly Import NAD+ Through an Unknown Transporter: Preclinical Findings

Synopsis Mitochondrial NAD+ is essential for choosing energy sources, maintaining daily rhythms, and helping cells survive stress. Scientists have debated whether mitochondria make NAD+ from cytos...

Nicotinamide Riboside Protects Against DNA Damage in Cells By Increasing NAD+: Preclinical Findings

Synopsis Mitochondrial cytochrome c oxidase (COX, complex IV) helps cells make energy. When COX is deficient, it can cause neuromuscular problems and sometimes anemia. Researchers found that COX4-...

Nicotinamide Riboside Improves Mitochondrial Defects and Neuronal Loss in Parkinson's Disease: Preclinical Findings

Synopsis Mitochondrial problems are thought to play a major role in Parkinson’s disease (PD), but it’s unclear if fixing them can slow the disease. Using patient-derived stem cells and fruit fly m...

Nicotinamide Riboside Protects Organs and Improves Survival in Sepsis: Preclinical Findings

Synopsis Sepsis, a life-threatening condition caused by the body’s extreme response to infection, often leads to multiple organ failure and remains one of the top causes of death in intensive care...

Effects of Nicotinamide Riboside on Mitochondrial Function in Rare Mitochondrial Disorder: Preclinical Findings

Synopsis Nicotinamide riboside (NR), a vitamin B3 derivative and precursor to NAD+, is known to support mitochondrial function and energy metabolism in many conditions. Researchers tested whether ...

CD38 Inhibitor Reverses Age-Related NAD+ Decline and Metabolic Dysfunction: Preclinical Findings

Synopsis Aging is characterized by the development of metabolic dysfunction and frailty. Recent studies show that a reduction in nicotinamide adenine dinucleotide (NAD+) is a key factor for the de...

Nicotinamide Riboside Converts into NAD+ without Breaking Down into Nicotinamide: Preclinical Findings

Synopsis NAD+ is a key molecule used in many cellular processes, not just energy production, but also in regulating important enzymes. Understanding how cells make NAD+ is therefore very important...

Tracking NAD+ Production and Breakdown Pathways: Preclinical Findings

Synopsis NAD+ (nicotinamide adenine dinucleotide) is a key molecule for metabolism and is used by important signaling enzymes like PARPs and sirtuins. NAD+ levels decline with age, so scientists a...

Effects of Senolytic Drugs on Human Stem-Like Cells: Preclinical Findings

Synopsis Senolytic drugs are believed to target and remove senescent cells, potentially rejuvenating tissues and improving health and lifespan in aging models. This study tested four senolytic com...

Nicotinamide Riboside Reduces Alcohol-Related Liver Damage: Preclinical Findings

Synopsis Alcohol causes liver damage by lowering the activity of SIRT1, a protein that regulates fat metabolism and mitochondrial function. Giving mice nicotinamide riboside (NR), an NAD+ precurso...

Nicotinamide Riboside Restores NAD+ Levels and Improves Mitochondrial Function in Skeletal Muscle Cells: Preclinical Findings

Synopsis Nicotinamide phosphoribosyltransferase (NAMPT) helps produce NAD+, which is essential for mitochondrial function and energy balance in skeletal muscle cells. Using gene techniques to redu...