Article: Nicotinamide Riboside Restores NAD+ Levels and Improves Mitochondrial Function in Skeletal Muscle Cells: Preclinical Findings

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Liver Disease Liver Health Preclinical

Nicotinamide Riboside Restores NAD+ Levels and Improves Mitochondrial Function in Skeletal Muscle Cells: Preclinical Findings

Synopsis

Nicotinamide phosphoribosyltransferase (NAMPT) helps produce NAD+, which is essential for mitochondrial function and energy balance in skeletal muscle cells. Using gene techniques to reduce NAMPT in muscle cells and mouse muscle, researchers found that lowering NAMPT decreased NAD+ levels and weakened mitochondrial respiration. This caused cells to rely more on glycolysis for energy, increasing glucose uptake. Treating cells with nicotinamide riboside, a NAD+ precursor, restored NAD+ and improved mitochondrial function. Reduced NAMPT also increased activity of genes regulated by hypoxia-inducible factor 1α (HIF-1α) and altered histone acetylation linked to SIRT6, suggesting the metabolic shift involves the SIRT6/HIF-1α pathway. Overall, NAMPT is crucial for maintaining NAD+ and proper energy metabolism in skeletal muscle.

Journal

American Journal of Physiology-Endocrinology and Metabolism

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