Nicotinamide Riboside Improves Alzheimer's Features and DNA Repair: Preclinical Findings

Synopsis Alzheimer’s disease (AD) involves problems with energy metabolism and DNA repair, but how these contribute to key AD features is unclear. A DNA repair-deficient AD mouse model (3xTgAD/Pol...

The Biology and Therapeutic Potential of Nicotinamide Riboside and Nicotinamide Mononucleotide: Review

SynopsisResearch on NAD+ biology has surged, especially around two intermediates—nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN)—which show promise in preventing and treating age-r...

Nicotinamide Riboside Protects Heart Function in Dilated Cardiomyopathy: Preclinical Findings

Synopsis In chronic heart failure, the heart’s energy metabolism is severely impaired. NAD+ is a key molecule that helps cells produce energy and respond to stress, making it an important focus in...

Nicotinamide Riboside Reduces Amyloid Plaque Formation and Improves Contextual Memory in Alzheimer's Disease: Preclinical Findings

Synopsis Alzheimer’s disease (AD) is a devastating neurodegenerative disorder driven by the accumulation of toxic amyloid-β (Aβ) protein aggregates. This study identifies a conserved mitochondrial...

Nicotinamide Riboside Supplementation Increases Blood NAD+ Levels in Healthy Humans: Clinical Findings

Objectives To determine the human pharmacokinetics of NR supplementation and its effect on whole blood nicotinamide adenine dinucleotide (NAD+) levels. Journal PLoS ONE Key Outcomes NR supplement...

Nicotinamide Riboside and Pterostilbene Safely Elevate NAD+ Levels in Humans: Clinical Findings

Objectives To evaluate the safety, tolerability, and efficacy of nicotinamide riboside and pterostilbene (NRPT) supplementation on sustaining elevated whole-blood NAD+ levels in healthy older adul...

Nicotinamide Riboside Restores Mitochondrial Function in Rev1-Deficient Cells: Preclinical Findings

Synopsis DNA, which carries the genetic information of all organisms, is constantly exposed to damage from both internal and external sources. If this damage—like single- or double-strand breaks—i...

Nicotinamide Riboside Protects Against Liver Toxicity: Preclinical Findings

Synopsis This study looked at the role of the mitochondrial enzyme MNADK, which makes NADP from NAD+, in liver health. Mice lacking MNADK had higher levels of certain amino acids and carnitines, a...

NAD+ in Aging: Molecular Mechanisms and Translational Implications: Review

SynopsisNAD+ is vital for energy production and helping cells adapt to stress, especially in high-energy tissues like the brain. NAD+ levels drop with age, contributing to chronic diseases such as ...

Nicotinamide Riboside Protects Neurons More Effectively Than NAD+: Preclinical Findings

Synopsis Loss of NAD+ is common in neurodegenerative diseases. Excitotoxicity, caused by excessive stimulation of neurons, leads to nerve damage. This study found that nicotinamide riboside (NR), ...

Purple Sweet Potato Anthocyanins and Nicotinamide Riboside Increase NAD+ Levels and Reduce Liver Inflammation: Preclinical Findings

Synopsis Purple sweet potato color (PSPC), a natural compound from purple sweet potatoes, can help protect the liver from damage caused by a high-fat diet. In mice fed a high-fat diet, PSPC reduce...

Modulating NAD+ Metabolism from Preclinical to Clinical Application: Review

SynopsisFirst discovered in the early 1900s, nicotinamide adenine dinucleotide (NAD+) was once seen only as a helper in energy reactions but is now known to be essential for many regulatory protein...

Nicotinamide Riboside Kinases Mediate NMN and NR Metabolism in Muscle Cells: Preclinical Findings

Synopsis Increasing NAD+ levels may help protect muscles from age-related decline. This study examined how skeletal muscle cells make NAD+ from precursors nicotinamide mononucleotide (NMN) and nic...

NAD+ Replenishment Prevents Thymus Atrophy and Liver Fat Accumulation: Preclinical Findings

Synopsis Dioxin (TCDD) is a highly toxic chemical that causes serious health problems like wasting, liver fat buildup, and thymus shrinkage in animals. Its toxic effects happen when it activates a...

Nicotinamide Riboside Prevents and Reverses Chemotherapy-Induced Peripheral Neuropathy: Preclinical Findings

Synopsis Damage to sensory nerves can cause peripheral neuropathy after chemotherapy. Increasing levels of nicotinamide adenine dinucleotide (NAD+) can protect nerves from injury. This study teste...

Nicotinamide Riboside Decreased DNA Damage in Liver Cells: Preclinical Findings

Synopsis Hepatocellular carcinoma (HCC) is a fast-growing liver cancer, but its exact origin has been unclear. Using human data and mouse models, researchers found that HCC starts mainly from live...

NAD+ Biosynthesis Enzyme Protects Aortic Smooth Muscle Cells: Preclinical Findings

Synopsis The walls of the aorta weaken with age and stress, risking serious damage. Smooth muscle cells (SMCs) in the aorta need NAD+, made by the enzyme NAMPT, for health. In humans with aortic d...

SARM1 Enzyme Drives Axonal NAD+ Loss and Degeneration: Preclinical Findings

Synopsis Axonal degeneration, or the breakdown of nerve fibers, happens early in many neurological diseases. The protein SARM1 is a key driver of this process, causing axons to lose NAD+, a vital ...

Altered NAD+ and Glutathione Metabolism in Fatty Liver Disease: Preclinical Findings

SynopsisIn patients with non-alcoholic fatty liver disease (NAFLD), researchers identified altered liver metabolism, specifically increased demand for NAD+ and glutathione (GSH), a key antioxidant....

Nicotinamide Riboside Dose Improves Metabolic Flexibility: Preclinical Findings

SynopsisMetabolic flexibility—the ability to switch between burning carbs and fats—is a marker of metabolic health. To study NR's effect on this, mice on a mildly obese diet received varying NR dos...