Early-Life Nicotinamide Riboside and Resveratrol Supplementation Improves Long-Term Metabolic Health: Preclinical Findings

Synopsis

This study explores how early-life nutritional supplementation with resveratrol (RSV) and nicotinamide riboside (NR)—both compounds known for their anti-obesity and metabolic-enhancing effects—influences long-term metabolic health. Newborn mice were given mild doses of RSV or NR during lactation and later tested as adults under normal- and high-fat diet conditions. In male mice, early supplementation led to delayed weight gain, healthier leptin/adiponectin balance, and evidence of white-to-brown fat remodeling (beige adipocyte formation) in white adipose tissue. These adaptive thermogenic changes suggest improved metabolic flexibility and resistance to diet-induced obesity. The findings indicate that nutritional interventions during early development can have lasting, sex-specific effects on fat metabolism, potentially reducing obesity risk later in life.

Journal

Molecular Nutrition & Food Research