Article: Nicotinamide Riboside Reduces Alcohol-Related Liver Damage: Preclinical Findings

PrevNext
Muscle Health Preclinical

Nicotinamide Riboside Reduces Alcohol-Related Liver Damage: Preclinical Findings

Synopsis

Alcohol causes liver damage by lowering the activity of SIRT1, a protein that regulates fat metabolism and mitochondrial function. Giving mice nicotinamide riboside (NR), an NAD+ precursor, restored NAD+ levels, activated SIRT1, improved mitochondrial function, and reduced fat buildup in the liver caused by alcohol. In liver cells, NR also reduced fat accumulation, but this effect disappeared when SIRT1 was blocked. These results show NR protects the liver from alcohol damage by boosting NAD+, which activates SIRT1 and supports healthy mitochondria.

Journal

Redox Biology

Share

Read more

Liver Disease

Nicotinamide Riboside Restores NAD+ Levels and Improves Mitochondrial Function in Skeletal Muscle Cells: Preclinical Findings

Synopsis Nicotinamide phosphoribosyltransferase (NAMPT) helps produce NAD+, which is essential for mitochondrial function and energy balance in skeletal muscle cells. Using gene techniques to redu...

Read more
Metabolic Health

Effects of Senolytic Drugs on Human Stem-Like Cells: Preclinical Findings

Synopsis Senolytic drugs are believed to target and remove senescent cells, potentially rejuvenating tissues and improving health and lifespan in aging models. This study tested four senolytic com...

Read more