Article: Nicotinamide Riboside Reduces Alcohol-Related Liver Damage: Preclinical Findings

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Muscle Health Preclinical

Nicotinamide Riboside Reduces Alcohol-Related Liver Damage: Preclinical Findings

Synopsis

Alcohol causes liver damage by lowering the activity of SIRT1, a protein that regulates fat metabolism and mitochondrial function. Giving mice nicotinamide riboside (NR), an NAD+ precursor, restored NAD+ levels, activated SIRT1, improved mitochondrial function, and reduced fat buildup in the liver caused by alcohol. In liver cells, NR also reduced fat accumulation, but this effect disappeared when SIRT1 was blocked. These results show NR protects the liver from alcohol damage by boosting NAD+, which activates SIRT1 and supports healthy mitochondria.

Journal

Redox Biology

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Liver Health

Nicotinamide Riboside Kinases Mediate NMN and NR Metabolism in Muscle Cells: Preclinical Findings

Synopsis Increasing NAD+ levels may help protect muscles from age-related decline. This study examined how skeletal muscle cells make NAD+ from precursors nicotinamide mononucleotide (NMN) and nic...

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Cardiovascular Disease

Nicotinamide Riboside Protects Heart Function in Dilated Cardiomyopathy: Preclinical Findings

Synopsis In chronic heart failure, the heart’s energy metabolism is severely impaired. NAD+ is a key molecule that helps cells produce energy and respond to stress, making it an important focus in...

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