Nicotinamide Riboside Protects Organs and Improves Survival in Sepsis: Preclinical Findings

Synopsis

Sepsis, a life-threatening condition caused by the body’s extreme response to infection, often leads to multiple organ failure and remains one of the top causes of death in intensive care units. Researchers have found that nicotinamide riboside (NR), a vitamin B3 derivative and precursor to NAD+, may help protect vital organs such as the heart and lungs during sepsis. In mouse models of sepsis, NR supplementation boosted NAD+ levels, reduced oxidative stress and inflammation, and significantly improved survival rates. NR also lowered levels of HMGB1, a major inflammatory molecule that contributes to tissue damage. Laboratory studies confirmed that NR prevented cell death and oxidative injury in both immune and vascular cells. These protective effects were linked to activation of the NAD+/SIRT1 pathway, a key regulator of metabolism and cellular defense. When this pathway was blocked, NR’s benefits disappeared, confirming its central role. Because nicotinamide riboside is already available as a safe dietary supplement, the findings suggest it could be developed into a preventive or supportive therapy for sepsis-related organ injury.

Journal

Free Radical Biology and Medicine