Article: High-Dose Nicotinamide Riboside Supplementation Is Safe and Effective: Clinical Findings

Aug 22, 2025 Clinical Liver Health Metabolic Health Pharmacokinetic/Safety

High-Dose Nicotinamide Riboside Supplementation Is Safe and Effective: Clinical Findings

Objectives

To test the safety of NR supplementation and its potential to improve insulin sensitivity and other metabolic parameters in obese, insulin-resistant men.

Journal

The American Journal of Clinical Nutrition

Key Outcomes

NR-supplemented subjects had an average 2% absolute reduction in liver fat content compared to a 0.2% absolute reduction in the placebo group.
Of the subset of men who started the trial with greater than 5% liver fat, 69% experienced a reduction in liver fat compared to only 39% of the men taking the placebo.
NR supplementation tended to decrease circulating levels of alanine aminotransferase (ALT) in the blood.

Duration

12 weeks

Dose

2000 mg

Study Design

Randomized, double-blind, placebo-controlled, parallel assignment study in 40 healthy, obese, sedentary men

See Published Study

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