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Early-Life Nicotinamide Riboside Supplementation Protects Against Obesity and Fatty Liver: Preclinical Findings
Synopsis
Nicotinamide riboside (NR), a vitamin B3 derivative and NAD+ precursor, is known for its anti-aging and metabolic health benefits, but its long-term effects when given early in life are less understood. In this study, baby mice were given small daily doses of NR during the first few weeks after birth and later fed either a normal or high-fat diet as adults. Mice that received early NR supplementation were protected from fat buildup in the muscles and liver, showed lower triglyceride levels, and had healthier fat metabolism compared to controls. These benefits were linked to the activation of SIRT1 and AMPK, two key proteins that regulate energy balance and fat burning. The results suggest that early-life NR supplementation may help program the body’s metabolism to resist obesity and fatty liver disease later in life by improving how cells manage energy and fat.
Journal
Nutrients