Article: Nicotinamide Riboside Protects Heart Function and Survival After Circadian Disruption: Preclinical Findings

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Cardiovascular Disease Cardiovascular Health Preclinical

Nicotinamide Riboside Protects Heart Function and Survival After Circadian Disruption: Preclinical Findings

Synopsis

The circadian clock, which regulates daily biological rhythms, also plays an important role in heart health. In this study, mice lacking REV-ERB receptors—key circadian regulators in the heart—developed heart failure and died prematurely due to a sharp decline in NAD+, a molecule vital for energy production. When these mice were given nicotinamide riboside (NR), a vitamin B3 derivative that boosts NAD+ levels, their heart function improved and their lifespan was extended. The findings show that restoring NAD+ levels can protect the heart even when circadian clock function is disrupted, highlighting a strong connection between energy metabolism, daily biological rhythms, and cardiovascular health.

Journal

Frontiers in Molecular Medicine

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