Article: Nicotinamide Riboside and Natural Antioxidants Protect Against Radiation Damage and Improve Survival: Preclinical Findings

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Cellular Health Preclinical

Nicotinamide Riboside and Natural Antioxidants Protect Against Radiation Damage and Improve Survival: Preclinical Findings

Synopsis

Researchers tested whether natural compounds could protect against harmful ionizing radiation, which has applications in medicine, space travel, and biotechnology. In mice exposed to lethal gamma radiation, a combination of plant-derived antioxidants pterostilbene (PT) and silibinin (SIL) improved survival, with 100% surviving 30 days and 20% surviving one year. Adding nicotinamide riboside (NR, a vitamin B3 derivative) and FSL1 further boosted long-term survival to 90% at one year. The protection worked by activating antioxidant defenses, repairing DNA, reducing inflammation, supporting energy metabolism, and helping blood cell recovery. Importantly, the treatment did not interfere with radiation therapy against tumors. This study suggests that combining PT, SIL, NR, and FSL1 could offer long-term protection against radiation in mammals.

Journal

Journal of Advanced Research

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