Article: Nicotinamide Riboside Restores Memory and Protects the Brain After Stroke: Preclinical Findings

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Cardiovascular Health Neurological Health Preclinical

Nicotinamide Riboside Restores Memory and Protects the Brain After Stroke: Preclinical Findings

Synopsis

After a stroke, the brain suffers from a sudden loss of blood flow that damages neurons and causes memory problems. This study found that treating mice with nicotinamide riboside chloride (NRC)—a vitamin B3 derivative and NAD+ booster—shortly after stroke significantly improved learning and memory recovery. The treatment reduced hippocampal damage, neuronal death, and infarct size while increasing energy production (ATP) and activating key protective proteins like SIRT1 and AMPK, which support cell survival and metabolism. By restoring NAD+ levels and enhancing mitochondrial energy supply, NR treatment protected brain cells and aided cognitive recovery after ischemia. These findings suggest that early NR supplementation could be a promising therapy for stroke recovery.

Journal

Neurochemical Research

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