Article: NAD+ Precursors Restore Mitochondrial Function and Prevent Nerve Damage in Diabetes: Preclinical Findings

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Diabetes Metabolic Health Neurological Health Neuropathy Preclinical

NAD+ Precursors Restore Mitochondrial Function and Prevent Nerve Damage in Diabetes: Preclinical Findings

Synopsis

Diabetic peripheral neuropathy involves nerve degeneration linked to low NAD+ levels. Researchers tested whether NAD+ precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) could prevent neuropathy in mouse and rat diabetes models. Treatment improved nerve function, prevented nerve fiber loss, and restored mitochondrial capacity in nerve cells, without affecting blood sugar or insulin. This suggests boosting NAD+ in nerves may be enough to protect against diabetic neuropathy.

Journal

International Journal of Molecular Sciences

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SynopsisSelective removal of damaged mitochondria (mitophagy) is crucial for cell health. Human cells show active basal mitophagy, mediated by the PINK1/Parkin pathway and p62 as a receptor. Mitoph...

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