Nicotinamide Riboside Reduces and Prevents Chemotherapy-Induced Peripheral Neuropathy: Preclinical Findings

Synopsis

Chemotherapy often causes peripheral neuropathy with no effective treatments. This study showed that NR, which activates the NAD-dependent enzyme SIRT2, prevents and reverses nerve damage caused by cisplatin chemotherapy in mice. NR's protective effects require SIRT2 but do not reduce chemotherapy's ability to kill cancer cells—in some cases, NR may enhance cancer cell sensitivity. These findings highlight NR as a potential therapy to reduce chemotherapy nerve toxicity.

Journal

Neuro-Oncology Advances