Article: Nicotinamide Riboside Regulates Inflammation and Improves Mitochondrial Function in Liver Cells: Preclinical Findings

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Liver Disease Liver Health Mitochondrial Health Preclinical

Nicotinamide Riboside Regulates Inflammation and Improves Mitochondrial Function in Liver Cells: Preclinical Findings

Synopsis

This study examined the effects of nicotinamide riboside (NR), a vitamin B3 derivative, on liver cells. Mouse hepatocytes were treated with palmitic acid to mimic fat-induced stress, then exposed to NR. NR did not harm cell viability, but it increased the activity and expression of sirtuins (Sirt1 and Sirt3), which help regulate metabolism and protect cells. NR reduced inflammatory markers such as TNF-α and IL-6, increased anti-inflammatory adiponectin, and lowered fetuin-A levels. Additionally, NR boosted mitochondrial markers related to energy production and mitochondrial health, including PGC-1α, CPT1, UCP2, and mitochondrial DNA. Overall, NR helped reduce liver inflammation and enhance mitochondrial function.

Journal

Nutrition Research and Practice

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Synopsis Increasing NAD+ levels to repair damaged mitochondria is a promising strategy for treating Alzheimer’s disease (AD) and other forms of dementia. Nicotinamide riboside (NR) is a safe NAD+ ...

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