Neonatal Resveratrol and Nicotinamide Riboside Supplementation Increase Energy-Burning Fat Development: Preclinical Findings

Synopsis

Early nutrition can influence how fat cells develop and function later in life, impacting metabolism and long-term health. This study explored how early-life supplementation with nicotinamide riboside (NR) or the polyphenol resveratrol (RSV) affects the development of fat tissue in mice. Newborn mice received NR or RSV for the first 20 days of life. Later, researchers studied cells from white and brown fat tissue. They found that in male mice, NR and RSV increased the expression of genes that promote brown-like (beige) fat development and improve fat-burning and energy metabolism. In female mice, these effects were reduced or even reversed. These findings suggest that early dietary interventions can “program” fat cells toward a healthier, energy-burning state later in life, and that the effects differ between males and females.

Journal

Frontiers in Physiology