Article: NAD-Related Compounds Affect Immune Cell Growth and Inflammatory Response: Preclinical Findings

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Immune Health Inflammation Preclinical

NAD-Related Compounds Affect Immune Cell Growth and Inflammatory Response: Preclinical Findings

Synopsis

Nicotinamide (NAM), nicotinamide riboside (NR), and 1-methylnicotinamide (MNA) are compounds related to NAD+ that play important roles in cell signaling, including in the immune system. Scientists studied how these compounds affect THP-1 cells, which are a model for monocytes and macrophages—cells involved in inflammation. When treated with NAM, NR, and MNA, the cells grew more slowly and more of them stayed in an early stage of the cell cycle (G0/G1), without changes in usual cell cycle regulators like p21 and p53. NAM and NR increased NAD levels inside the cells and raised the activity of genes called SIRT1 and PARP1. However, these compounds did not increase signs of the cells maturing into specialized immune cells (markers CD38, CD11b, CD14). They did change the production of reactive oxygen species and made the cells less responsive to an inflammatory trigger (LPS-induced TNF-α). Overall, these NAD-related compounds affect early development steps of immune cells and change how they respond to inflammation.

Journal

Innate Immunity

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