Article: Nicotinamide Riboside Reduces Brain Inflammation and Improves Cognitive Function in Diabetic Mice: Preclinical Findings

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Diabetes Metabolic Health Neurological Health Preclinical

Nicotinamide Riboside Reduces Brain Inflammation and Improves Cognitive Function in Diabetic Mice: Preclinical Findings

Synopsis

This study tested whether nicotinamide riboside (NR) can reduce brain inflammation and improve cognitive function in diabetic mice. Mice with diet- and chemically-induced diabetes were given NR for six weeks. NR lowered inflammatory markers in the brain, including IL-1, TNF-α, IL-6, NLRP3, ASC, and caspase-1, and reduced amyloid-β and related proteins linked to cognitive decline. NR also improved hippocampal function, spatial memory, and locomotor activity, and reversed diabetes-induced brain cell damage. These results suggest that NR may help prevent cognitive impairment in diabetes by reducing neuroinflammation and amyloid accumulation.

Journal

International Journal of Molecular Sciences

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