Article: Nicotinamide Riboside Rejuvenates Aging Gut Stem Cells: Preclinical Findings

PrevNext
Nicotinamide Riboside Rejuvenates Aging Gut Stem Cells: Preclinical Findings
Muscle Health Preclinical

Nicotinamide Riboside Rejuvenates Aging Gut Stem Cells: Preclinical Findings

Synopsis

Aging leads to tissue decline partly due to reduced function of adult stem cells. In the intestine, the number and activity of intestinal stem cells (ISCs) decrease with age, while Paneth cells remain unchanged. Levels of SIRT1 and mTORC1 activity also drop during aging. Supplementing with the NAD+ precursor nicotinamide riboside (NR) rejuvenates ISCs in aged mice and restores their ability to repair gut damage. This benefit is blocked when mTORC1 or SIRT1 is inhibited. These results suggest that targeting the NAD/SIRT1/mTORC1 pathway with small molecules like NR may help maintain intestinal health during aging.

Journal

Aging Cell

Share

Read more

COVID/Long-COVID

NAD+ Biosynthesis Enzyme Protects Aortic Smooth Muscle Cells: Preclinical Findings

Synopsis The walls of the aorta weaken with age and stress, risking serious damage. Smooth muscle cells (SMCs) in the aorta need NAD+, made by the enzyme NAMPT, for health. In humans with aortic d...

Read more
Alzheimer's Disease

Nicotinamide Riboside Reduces Brain Inflammation and Cellular Aging in Alzheimer’s Disease: Preclinical Findings

Synopsis In Alzheimer’s disease, brain cells often show low NAD+ levels, high inflammation, and impaired cellular cleanup of damaged components. In mice with Alzheimer’s-like brain changes, five m...

Read more