Article: Nicotinamide Riboside Enhances Milk Production in Lactating Sows: Preclinical Findings

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Preclinical Reproductive Health

Nicotinamide Riboside Enhances Milk Production in Lactating Sows: Preclinical Findings

Synopsis

Lactation insufficiency is a common challenge with unclear biological causes. This study examined how nicotinamide riboside (NR), a vitamin B3–derived NAD+ precursor, influences mammary gland (MG) metabolism and milk production in lactating sows. NR supplementation significantly increased NAD+ levels in mammary tissue and milk, enhanced lactogenesis gene expression, and expanded alveolar lumen area, improving the gland’s secretory capacity. NR-fed sows produced 31% more milk, while their offspring showed higher growth rates, better cold tolerance, and stronger gut integrity. Mechanistically, NR activated the NAD+-SIRT1 pathway, increasing mitochondrial density and biogenesis, which improved cellular energy and milk synthesis. These findings demonstrate that NR restores mammary NAD+ metabolism, promoting efficient milk production and neonatal health, and may serve as a potential therapy for lactation insufficiency.

Journal

The Journal of Nutrition

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