Reishi Mushroom Delays Kidney Aging Through Gut Microbiota and Nicotinamide Riboside: Preclinical Findings

Synopsis

Ganoderma lucidum (G. lucidum), also known as Reishi mushroom, has been valued in traditional Chinese medicine (TCM) for its anti-aging and kidney-protective properties. This study explored how G. lucidum exerts these effects through the gut–kidney axis using advanced multi-omics approaches in both naturally aged and radiation-induced premature aging mouse models. Treatment with G. lucidum spore powder (Gl-SBSP) reduced kidney tissue damage, improved renal function, and alleviated systemic aging symptoms. Gut microbiome analysis revealed that Gl-SBSP specifically increased the abundance of Lachnospiraceae, a beneficial bacterial family that produces nicotinamide riboside (NR)—a vitamin B3–derived NAD+ precursor known to enhance cellular energy and longevity. The microbiota-derived NR raised renal NAD+ levels, rejuvenated senescent kidney cells, and improved steroid metabolism. When gut bacteria were depleted or transplanted, these benefits were lost or transferred, confirming the microbiome’s central role. The findings reveal that G. lucidum combats kidney aging by stimulating gut bacteria to produce NR, which in turn activates NAD+ biosynthesis and restores metabolic balance—providing a scientific explanation for its traditional anti-aging use.

Journal

Journal of Ethnopharmacology