%20increases%20vulnerability%20to%20acute%20kidney%20injury%20(AKI).%20In%20a%20rat%20model%20where%20ischemia%E2%80%93reperfusion%20injury%20(IRI)%20was%20applied%20on%20top%20of%20sCKD,%20a%20dual%20t...){kind=link}
Nicotinamide Riboside Reduces Kidney Damage in Chronic Disease: Preclinical Findings
Synopsis
Subclinical chronic kidney disease (sCKD) increases vulnerability to acute kidney injury (AKI). In a rat model where ischemia–reperfusion injury (IRI) was applied on top of sCKD, a dual treatment combining nicotinamide riboside (NR) to boost NAD+ and the mitochondrial antioxidant SkQR1 preserved kidney functional reserve, reduced structural damage, and improved vascular integrity and blood volume. The treatment activated protective pathways—including Sirt1, Nrf2, and PGC-1α—enhancing mitochondrial biogenesis and antioxidant gene expression. These results show that targeting mitochondrial health and redox balance provides strong, long-term protection against kidney injury in the setting of sCKD.
Journal
International Journal of Molecular Sciences