Nicotinamide Riboside Protects Against Doxorubicin-Induced Liver and Kidney Toxicity: Preclinical Findings

Synopsis Doxorubicin (DOX) is a powerful chemotherapy drug, but its use is limited because it causes serious liver and kidney toxicity through ferroptosis, an iron-dependent form of cell death dri...

Reishi Mushroom Delays Kidney Aging Through Gut Microbiota and Nicotinamide Riboside: Preclinical Findings

Synopsis Ganoderma lucidum (G. lucidum), also known as Reishi mushroom, has been valued in traditional Chinese medicine (TCM) for its anti-aging and kidney-protective properties. This study explor...

NAD+ Deficiency Drives Kidney Dysfunction in Cockayne Syndrome: Preclinical Findings

SynopsisCockayne Syndrome (CS) is a premature aging disorder caused by mutations in the CSA and CSB genes, leading to problems like early aging, nerve damage, and kidney dysfunction. Cells from CS ...

Nicotinamide Riboside Reduces Kidney Damage in Chronic Disease: Preclinical Findings

Synopsis Subclinical chronic kidney disease (sCKD) increases vulnerability to acute kidney injury (AKI). In a rat model where ischemia–reperfusion injury (IRI) was applied on top of sCKD, a dual t...

Nicotinamide Riboside Protects Against Chronic Kidney Disease by Boosting Metabolism: Preclinical Findings

SynopsisChronic kidney disease (CKD) impairs kidney metabolism, including fatty acid breakdown, and is linked to low NAD+ levels. This study tested nicotinamide riboside (NR), a precursor of NAD+, ...

Nicotinamide Riboside Protects Kidneys after Heart Attack: Preclinical Findings

SynopsisCardiorenal syndrome type 1 occurs when acute kidney injury (AKI) develops after sudden heart problems like a heart attack (MI), increasing the risk of death. This study tested whether nico...

Nicotinamide Riboside Restores NAD+ and Improves Mitochondrial Function in HIV-Nephropathy: Preclinical Findings

SynopsisHIV disease remains prevalent in the United States and especially in sub-Saharan Africa. In mice with HIV-associated kidney disease (HIVAN), their kidney cells showed mitochondrial dysfunct...

NMRK2 Serves as a Diagnostic Biomarker for Renal Cell Carcinoma: Preclinical Findings

Synopsis Xp11.2 translocation renal cell carcinoma (tRCC) is a rare and aggressive form of kidney cancer that currently lacks reliable diagnostic tools and effective treatments. This study identif...

Nicotinamide Riboside Protects Mitochondria in Aging Kidneys: Preclinical Findings

SynopsisAs kidneys age, their cells, especially in the distal tubules, undergo changes in mitochondrial structure and function, but little is known about how aging or anti-aging interventions affec...

Nicotinamide Riboside and Nicotinamide Mononucleotide Protect Against Kidney Injury: Preclinical Findings

Synopsis This study uncovered how NAD+ deficiency contributes to kidney disease by damaging mitochondria and triggering inflammation. Through metabolic analysis of human kidney samples, researcher...

Nicotinamide Riboside Prevents Low Kidney Nephron Numbers Caused by Maternal Protein Restriction: Preclinical Findings

SynopsisBabies born with fewer nephrons (kidney filters), often due to poor maternal nutrition, have higher risk for kidney disease and high blood pressure later. There are no current treatments to...

Nicotinamide Riboside Restores NAD+ and Autophagy After Kidney Injury: Preclinical Findings

Synopsis Acute kidney injury (AKI) can quickly lead to kidney failure and increase the risk of developing chronic kidney disease (CKD). In this study, scientists tested whether nicotinamide ribosi...

Nicotinamide Riboside Protects Against Acute Kidney Injury but Not Chronic Kidney Disease: Preclinical Findings

Synopsis Nicotinamide adenine dinucleotide (NAD+) is essential for kidney function, but its production is impaired in acute kidney injury (AKI) and chronic kidney disease (CKD). In human kidney bi...

Nicotinamide Riboside and Pterostilbene Increase NAD+ Levels in Patients with Acute Kidney Injury: Clinical Findings

Objectives To evaluate the effects of escalating doses of nicotinamide riboside and pterostilbene (NRPT) on blood NAD+ levels and safety outcomes in patients hospitalized with acute kidney injury ...

Effects of Nicotinamide Riboside Against Kidney Injury: Preclinical Findings

Synopsis Sirtuin 3 (Sirt3) is an important protein that helps regulate energy use and protect cells from stress. Researchers studied its role in contrast-induced acute kidney injury (CIAKI) using ...