Nicotinamide Riboside Restores NAD+ and Improves Mitochondrial Function in HIV-Nephropathy: Preclinical Findings

SynopsisHIV disease remains prevalent in the United States and especially in sub-Saharan Africa. In mice with HIV-associated kidney disease (HIVAN), their kidney cells showed mitochondrial dysfunct...

Nicotinamide Riboside Protects Mitochondria in Aging Kidneys: Preclinical Findings

SynopsisAs kidneys age, their cells, especially in the distal tubules, undergo changes in mitochondrial structure and function, but little is known about how aging or anti-aging interventions affec...

Nicotinamide Riboside Protects Kidneys after Heart Attack: Preclinical Findings

SynopsisCardiorenal syndrome type 1 occurs when acute kidney injury (AKI) develops after sudden heart problems like a heart attack (MI), increasing the risk of death. This study tested whether nico...

Nicotinamide Riboside Protects Against Chronic Kidney Disease by Boosting Metabolism: Preclinical Findings

SynopsisChronic kidney disease (CKD) impairs kidney metabolism, including fatty acid breakdown, and is linked to low NAD+ levels. This study tested nicotinamide riboside (NR), a precursor of NAD+, ...

Nicotinamide Riboside Prevents Low Kidney Nephron Numbers Caused by Maternal Protein Restriction: Preclinical Findings

SynopsisBabies born with fewer nephrons (kidney filters), often due to poor maternal nutrition, have higher risk for kidney disease and high blood pressure later. There are no current treatments to...

NAD+ Deficiency Drives Kidney Dysfunction in Cockayne Syndrome: Preclinical Findings

SynopsisCockayne Syndrome (CS) is a premature aging disorder caused by mutations in the CSA and CSB genes, leading to problems like early aging, nerve damage, and kidney dysfunction. Cells from CS ...