Article: Nicotinamide Riboside Alleviates Bone Cancer Pain by Restoring Mitochondrial Function: Preclinical Findings

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Bone Health Cancer Preclinical

Nicotinamide Riboside Alleviates Bone Cancer Pain by Restoring Mitochondrial Function: Preclinical Findings

Synopsis

Bone cancer pain (BCP) disrupts mitochondrial function in spinal cord neurons, leading to damaged mitochondrial structure, reduced ATP production, and decreased membrane potential (MMP). This mitochondrial stress activates the mitochondrial unfolded protein response (UPRmt), marked by increased Atf5, Hsp60, LonP1, and ClpP expression—especially Atf5 in dorsal horn neurons. Enhancing UPRmt with nicotinamide riboside (NR) significantly reduced pain behaviors, restored ATP levels, and recovered mitochondrial membrane potential. Silencing Atf5 eliminated these protective effects, confirming that NR alleviates BCP by boosting Atf5-dependent UPRmt activity. These findings highlight UPRmt activation as a promising therapeutic approach for treating bone cancer pain.

Journal

Experimental Cell Research

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