Article: Nicotinamide Riboside Protects Against Diet-Induced Liver Injury: Preclinical Findings

PrevNext
Liver Health Metabolic Health Preclinical

Nicotinamide Riboside Protects Against Diet-Induced Liver Injury: Preclinical Findings

Synopsis

Nicotinamide riboside (NR), a precursor to NAD+, helps prevent metabolic and age-related disorders in mice, but the role of naturally occurring NR metabolism is less understood. Researchers studied mice lacking NR kinase 1 (NRK1), an enzyme essential for NR to boost NAD+ in the liver. Mice without NRK1 showed reduced glucose production, impaired mitochondrial function, and worse metabolic health. When fed a high-fat diet, these mice developed glucose intolerance, insulin resistance, fatty liver, and DNA damage in the liver. This shows that endogenous NR metabolism via NRK1 is critical to maintain liver NAD+ levels and protect against diet-induced metabolic problems, suggesting NRK1 could be a target for treating metabolic disorders.

Journal

Nature Communications

Share

Read more

Immune Health

NAD+ Levels Control Inflammatory Responses in Immune Cells: Preclinical Findings

SynopsisNAD+ is important for cell metabolism and inflammation, but how it affects immune cells is not well understood. This study looked at how changing NAD+ levels using nicotinamide riboside (NR...

Read more
Liver Disease

Effects of High-Dose Nicotinamide Riboside on White Fat Tissue Function and Insulin Sensitivity: Preclinical Findings

Synopsis Nicotinamide riboside (NR) is a vitamin that helps produce NAD+, a key molecule for metabolism. Although reports of negative effects from high doses of NR are rare, this study examined ho...

Read more