%20is%20a%20disease%20where%20motor%20neurons%20progressively%20degenerate,%20leading%20to%20muscle%20weakness%20and%20paralysis.%20Declines%20in%20NAD+%20contribute%20to%20mitochondrial%20dysfu...){kind=link}
Nicotinamide Riboside Supports Mitochondrial Health and Neurogenesis in ALS: Preclinical Findings
Synopsis
Amyotrophic lateral sclerosis (ALS) is a disease where motor neurons progressively degenerate, leading to muscle weakness and paralysis. Declines in NAD+ contribute to mitochondrial dysfunction, toxic protein accumulation, and impaired neural stem cell activity in the brain. In a mouse model of ALS, oral nicotinamide riboside (NR), a precursor to NAD+, improved endurance and enhanced the clearance of toxic mitochondrial SOD1 protein. NR also activated mitochondrial stress response pathways, supported mitochondrial function, and increased proliferation and migration of neural stem and progenitor cells, although it did not delay disease onset or extend lifespan. These findings suggest that NR can help restore NAD+ metabolism, improve mitochondrial proteostasis, and promote neurogenesis in ALS.
Journal
International Journal of Biological Sciences