Article: Neonatal Nicotinamide Riboside and Resveratrol Epigenetically Program White Fat Browning: Preclinical Findings

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Metabolic Health Methylation Preclinical

Neonatal Nicotinamide Riboside and Resveratrol Epigenetically Program White Fat Browning: Preclinical Findings

Synopsis

Giving newborn male mice resveratrol (RSV) or nicotinamide riboside (NR) can “program” their white fat to develop brown fat-like features (WAT browning) and improve metabolism later in life. This study explored whether these effects involve long-term epigenetic changes. Mice were given RSV or NR from day 2 to 20 after birth, then fed normal or high-fat diets as adults. Analysis of key browning genes (Slc27a1 and Prdm16) showed that both RSV and NR altered DNA methylation patterns in these genes and affected methylation dynamics under a high-fat diet. These treatments also influenced DNA methylation enzymes in young fat tissue. Cell studies confirmed RSV and NR can directly affect the DNA methylation machinery and promote browning. Overall, neonatal RSV or NR supplementation appears to reprogram fat tissue via epigenetic mechanisms in male mice.

Journal

Nutrients

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