%20is%20a%20form%20of%20vitamin%20B3%20that%20helps%20increase%20NAD+%20and%20improve%20mitochondrial%20function,%20but%20its%20effect%20on%20physical%20fitness%20is%20unclear.%20In%20a%20study%20with%20sedentary%20an...){kind=link}
Nicotinamide Ribosides Improves Aerobic Performance: Preclinical Findings
Synopsis
Nicotinamide riboside (NR) is a form of vitamin B3 that helps increase NAD+ and improve mitochondrial function, but its effect on physical fitness is unclear. In a study with sedentary and trained mice, NR was given daily for 5 or 10 weeks. Exercise training involved treadmill running five days a week. While NR alone did not improve aerobic performance, it did raise NAD+ levels in muscle. When combined with exercise, NR enhanced aerobic capacity more than exercise alone. This improvement was linked to increased amounts of enzymes involved in NAD+ production and mitochondrial proteins. Genetic analysis supported that the enzyme NMNAT3 correlates with mitochondrial health and exercise traits. Additionally, NR plus exercise increased the number of slow-twitch (type I) muscle fibers, which are better suited for endurance. Overall, these results indicate that NR, especially when combined with aerobic training, can boost muscle metabolism and improve endurance.
Journal
European Journal of Nutrition