NAD+ Levels Control Inflammatory Responses in Immune Cells: Preclinical Findings

Synopsis

NAD+ is important for cell metabolism and inflammation, but how it affects immune cells is not well understood. This study looked at how changing NAD+ levels using nicotinamide riboside (NR) or an inhibitor affects inflammation in human monocytes. When NAD+ was increased, the cells released more of the inflammatory molecule IL-1β after stimulation. Lowering NAD+ blocked inflammation signals, especially through the TLR4 pathway, without involving certain enzymes called sirtuins or PARP1. This shows NAD+ plays a new role in controlling inflammation, which is important for considering NR as a treatment for inflammatory diseases.

Journal

The Journal of Immunology