Article: Limited Effects of Quercetin and Nicotinamide Riboside in Duchenne Muscular Dystrophy: Preclinical Findings

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Muscle Health Preclinical

Limited Effects of Quercetin and Nicotinamide Riboside in Duchenne Muscular Dystrophy: Preclinical Findings

Synopsis

Duchenne muscular dystrophy causes progressive muscle weakness and damage. Researchers tested quercetin (Q), nicotinamide riboside (NR), lisinopril (Lis), and prednisolone (Pred), alone or combined, in dystrophin-deficient mice over 7 months to see if these treatments improved muscle function or reduced injury. None restored muscle strength or reduced tissue damage, though combined treatment slightly lessened contraction-induced injury. This study shows these treatments, despite prior promise, do not effectively prevent long-term muscle dysfunction or damage in this Duchenne model. Notably, the Duchenne model showed severe muscle dysfunction and damage, highlighting the challenge of treating Duchenne muscular dystrophy.

Journal

Journal of Applied Physiology

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Nicotinamide Riboside Restores NAD+ Levels and Improves Mitochondrial Function in Skeletal Muscle Cells: Preclinical Findings

Synopsis Nicotinamide phosphoribosyltransferase (NAMPT) helps produce NAD+, which is essential for mitochondrial function and energy balance in skeletal muscle cells. Using gene techniques to redu...

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Nicotinamide Riboside Prevents and Reverses Chemotherapy-Induced Peripheral Neuropathy: Preclinical Findings

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