Article: Limited Effects of Quercetin and Nicotinamide Riboside in Duchenne Muscular Dystrophy: Preclinical Findings

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Muscle Health Preclinical

Limited Effects of Quercetin and Nicotinamide Riboside in Duchenne Muscular Dystrophy: Preclinical Findings

Synopsis

Duchenne muscular dystrophy causes progressive muscle weakness and damage. Researchers tested quercetin (Q), nicotinamide riboside (NR), lisinopril (Lis), and prednisolone (Pred), alone or combined, in dystrophin-deficient mice over 7 months to see if these treatments improved muscle function or reduced injury. None restored muscle strength or reduced tissue damage, though combined treatment slightly lessened contraction-induced injury. This study shows these treatments, despite prior promise, do not effectively prevent long-term muscle dysfunction or damage in this Duchenne model. Notably, the Duchenne model showed severe muscle dysfunction and damage, highlighting the challenge of treating Duchenne muscular dystrophy.

Journal

Journal of Applied Physiology

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Effects of High-Dose Nicotinamide Riboside on White Fat Tissue Function and Insulin Sensitivity: Preclinical Findings

Synopsis Nicotinamide riboside (NR) is a vitamin that helps produce NAD+, a key molecule for metabolism. Although reports of negative effects from high doses of NR are rare, this study examined ho...

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Nicotinamide Riboside Helps Protect the Heart by Improving Mitochondrial Function: Preclinical Findings

Synopsis Endothelial-to-mesenchymal transition (EndMT) contributes to heart scarring (cardiac fibrosis), but how it happens and how to treat it is not fully known. Researchers found that a process...

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