Article: Nicotinamide Riboside and B Vitamins Restore Heart Energy in Heart Failure: Preclinical Findings

PrevNext
Cardiovascular Disease Cardiovascular Health Preclinical

Nicotinamide Riboside and B Vitamins Restore Heart Energy in Heart Failure: Preclinical Findings

Synopsis

Heart failure (HF) affects the heart’s energy supply, but current treatments do not directly fix this problem. In a study using mice with established HF, a diet supplemented with three B vitamins—nicotinamide riboside (NR), B9, and B12—helped improve heart function and energy metabolism. In male mice, the vitamin cocktail increased survival and reduced heart damage, while in females it improved physical performance and lessened heart cell stress. In both sexes, the treatment supported healthy mitochondria by maintaining mitochondrial biogenesis. These results suggest that NR combined with other B vitamins could be a promising metabolic therapy for heart failure, with some differences in effectiveness between males and females.

Journal

Biology of Sex Differences

Share

Read more

Inflammation

Nicotinamide Riboside Counteracts Alcohol-Induced Neurotoxicity: Preclinical Findings

Synopsis Excessive alcohol intake causes cognitive impairment and neuronal injury driven by oxidative stress, inflammation, and profound mitochondrial dysfunction. This study shows that NRC, an NA...

Read more
Arthritis

NAD+ Depletion Drives Cartilage Damage in Osteoarthritis: Preclinical Findings

Synopsis Earlier research showed that people with osteoarthritis (OA) have lower levels of NAD+, an important energy-related molecule, in their cartilage. This study found that NAD+ levels are red...

Read more