%20is%20a%20serious%20liver%20condition%20caused%20by%20excessive%20alcohol%20and%20has%20few%20effective%20nutritional%20treatments.%20Researchers%20found%20that%20brown%20fat%20cells%20release%20a%20prote...){kind=link}
Nicotinamide Riboside Reduces Liver Inflammation in Alcoholic Liver Disease: Preclinical Findings
Synopsis
Alcoholic liver disease (ALD) is a serious liver condition caused by excessive alcohol and has few effective nutritional treatments. Researchers found that brown fat cells release a protein called eNAMPT, which contributes to liver inflammation by activating the NLRP3 inflammasome in liver cells and immune cells. In experiments, removing eNAMPT reduced liver inflammation. Importantly, giving nicotinamide riboside (NR), a form of vitamin B3, suppressed eNAMPT release and lowered liver inflammation in both cells and mice. This suggests that NR could be a promising dietary strategy to reduce liver inflammation in ALD by targeting eNAMPT.
Journal
Food & Function