Article: Nicotinamide Riboside Improves Stroke Recovery by Modulating Monocyte Metabolism: Preclinical Findings

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Neuroinflammation Neurological Health Preclinical

Nicotinamide Riboside Improves Stroke Recovery by Modulating Monocyte Metabolism: Preclinical Findings

Synopsis

Aging worsens post-stroke outcomes by amplifying neuroinflammation. This study examined whether older circulating monocytes exhibit altered metabolism after stroke and whether boosting NAD+ with nicotinamide riboside (NR) can improve inflammatory responses and neurological recovery. Aging shifted monocytes toward a dysfunctional metabolic state that intensified brain inflammation after ischemia. Enhancing NAD⁺ availability with NR corrected these metabolic deficits, reduced neuroinflammatory signaling, and improved post-stroke functional outcomes. These findings highlight age-dependent monocyte metabolic dysfunction as a driver of poorer stroke recovery and identify NR-mediated NAD+ restoration as a potential therapeutic strategy.

Journal

Journal of Neuroinflammation

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