Nicotinamide Riboside Plus Magnesium-L-Theanine Protects Against Stress-Induced Gut–Liver Injury: Preclinical Findings

Synopsis

Chronic stress can harm the gut and liver by disrupting metabolism and causing oxidative damage. This study tested the protective effects of nicotinamide riboside (NR) and magnesium-L-theanine (MgT) in rats exposed to chronic variable stress (CVS), which included factors like water deprivation, cold exposure, and physical restraint. The rats that received NR and MgT showed improved health, with restored blood sugar, liver function, and magnesium levels. Their liver and gut also showed better structure and function, including improved protein expression and reduced inflammation. The results suggest that NR and MgT supplementation could help protect against stress-induced damage to the gut and liver, possibly by supporting NAD+ metabolism and improving barrier function, offering a potential treatment for stress-related health problems.

Journal

Molecular Biology Reports