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NAD+ Depletion Drives Cartilage Damage in Osteoarthritis: Preclinical Findings
Synopsis
Earlier research showed that people with osteoarthritis (OA) have lower levels of NAD+, an important energy-related molecule, in their cartilage. This study found that NAD+ levels are reduced in human and animal OA and that this drop is partly caused by increased activity of PARP14, an enzyme that consumes NAD+. Even though the body tries to make more NAD+, inflammation may limit its production. Raising NAD+ levels—through supplements like NMN or NR or by boosting a key NAD-producing enzyme—helped protect cartilage in aging and injury-based OA models. Overall, the findings suggest that faulty NAD+ metabolism contributes to OA and that restoring NAD+ may help slow the disease, though more research is needed.
Journal
Clinical and Translational Medicine