%20is%20a%20very%20aggressive%20cancer%20with%20few%20treatment%20options%20and%20a%20high%20ability%20to%20spread.%20This%20study%20found%20that%20TNBC%20cells%20use%20a%20process%20in%20their%20mitochond...){kind=link}
Impact of Energy Production Proteins and Molecules in Triple-Negative Breast Cancer: Preclinical Findings
Synopsis
Triple-negative breast cancer (TNBC) is a very aggressive cancer with few treatment options and a high ability to spread. This study found that TNBC cells use a process in their mitochondria called oxidative phosphorylation (OXPHOS) to make more energy, which helps them spread. The protein CDCP1 activates another protein called Src, which in turn boosts the energy-making process and increases NAD+ levels, helping the cancer cells move. Treatment with nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) increased NAD+ and restored the cancer cells' ability to move. Blocking CDCP1 or Src reduced energy production, movement, and spread of the cancer. Restoring the energy process reversed these effects, showing that it plays a key role in cancer spread. The study suggests that targeting CDCP1 and Src could help prevent TNBC from spreading by blocking NAD+ production.
Journal
British Journal of Cancer