NAD+ Precursors Restore Mitochondrial Function and Prevent Nerve Damage in Diabetes: Preclinical Findings

SynopsisDiabetic peripheral neuropathy involves nerve degeneration linked to low NAD+ levels. Researchers tested whether NAD+ precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside ...

Effects of Nicotinamide Riboside on Exercise Performance: Preclinical Findings

Synopsis This proof-of-concept study tested whether chronic nicotinamide riboside (NR) supplementation, a precursor of nicotinamide adenine dinucleotide (NAD+), could enhance physical performance ...

DNA Replication Stress Causes Complex Metabolic Changes: Preclinical Findings

SynopsisDNA replication stress occurs when cells struggle to copy damaged DNA, affecting metabolism. Using mice lacking the DNA polymerase Rev1, researchers observed sex-specific metabolic changes:...

Nicotinamide Riboside Alters Gut Microbiota to Reduce Weight Gain from High-Fat Diet in Mice: Preclinical Findings

SynopsisThe gut microbiome influences energy balance and obesity risk. Nicotinamide riboside (NR), a vitamin B3 form and NAD+ precursor, can reduce weight gain and increase energy use in obese mice...

Nicotinamide Riboside Has Minor Metabolic Benefits in Obesity: Preclinical Findings

SynopsisNicotinamide riboside supplements (NRS) are thought to boost NAD+ levels and mitochondrial function, potentially improving muscle health and energy use. This study tested NRS effects in nor...

Metabolic Cofactors Including Nicotinamide Riboside Improves Non-Alcoholic Fatty Liver Disease: Preclinical Findings

SynopsisNon-alcoholic fatty liver disease (NAFLD) is a common liver condition linked to obesity and metabolic problems, but no effective treatment exists. Researchers tested a combination of metabo...

Nicotinamide Riboside Reduces Brain Inflammation, Protects Muscle Health, and Enhances Weight Loss in Obesity: Preclinical Findings

Synopsis Obesity treatments like calorie restriction (CR) often cause muscle loss and increase brain inflammation, which can interfere with weight control. In this study, obese rats were given CR,...

Nicotinamide Riboside Has Minor Effect on Energy Metabolism in Obesity: Preclinical Findings

SynopsisNR has been shown to reverse obesity-related health issues in mice, but effects may vary by strain. Researchers compared mildly obese C57BL/6N and C57BL/6J mice on high-fat diets, with or w...

Nicotinamide Riboside Mitigates Cancer Cachexia: Preclinical Findings

Synopsis Cancer cachexia, a severe condition seen in advanced cancer patients, causes muscle loss, weight loss, and fat breakdown, greatly reducing quality of life and survival. This study found t...

Nicotinamide Riboside Rejuvenates Aged Hematopoietic Stem Cells and Improves Regeneration: Preclinical Findings

SynopsisWith age, hematopoietic stem cells (HSCs) lose their ability to regenerate and remain quiescent, leading to an expanded stem cell pool that can cause blood disorders. Researchers found that...

Nicotinamide Riboside Reduces Alcohol-Induced Inflammation and Oxidative Stress in Immune Cells: Preclinical Findings

SynopsisMacrophages play an important role in inflammation and oxidative stress caused by alcohol. Researchers studied how nicotinamide riboside (NR), a precursor of NAD+, affects alcohol-induced i...

The Effects of NAD+ Boosting on Cold-Stimulated Brown Adipose Tissue Activity: Clinical Findings

Objectives To investigate whether NR stimulates brown adipose tissue in humans. Journal The Journal of Clinical Endocrinology & Metabolism Key Outcomes NR supplementation had no effect on col...

Nicotinamide Riboside Enhances Muscle Growth and Fiber Density in Chicken Embryos: Preclinical Findings

Synopsis Researchers injected nicotinamide riboside (NR) into fertilized chicken eggs to study its effects on muscle growth. NR increased the weight, length, and width of the pectoral muscles in c...

Coronavirus Disrupts NAD+ Metabolism, While Nicotinamide Riboside Decreases Viral Replication: Preclinical Findings

Synopsis Certain enzymes called PARPs, which use NAD+ to modify proteins, play a role in the body’s defense against coronaviruses. Researchers found that SARS-CoV-2 infection increases the levels ...

Adult Zebrafish Provide an In Vivo Platform for Evaluating Drug Responses in Ethanol-Induced Acute Hepatic Injury: Preclinical FIndings

Synopsis Chronic alcohol use can damage the liver, but effective treatments are limited. Researchers developed an adult zebrafish model to quickly test drugs for alcohol-induced liver injury. Expo...

Nicotinamide Mononucleotide Improves Blood Vessel Function by Converting to Nicotinamide Riboside: Preclinical Findings

Synopsis Nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) are compounds that help make NAD+, which may protect blood vessels. Researchers studied how NMN and NR affect inflammation...

Nicotinamide Riboside Supplementation Modestly Improves Body Composition & Sleeping Metabolic Rate: Clinical Findings

Objectives To investigate the effects of NR supplementation on insulin sensitivity, mitochondrial function, and other metabolic health parameters in overweight and obese volunteers. Journal The Am...

NAD+ Precursors Nicotinamide Riboside and Nicotinamide Regulate Cardiac Sodium Channels: Preclinical Findings

Synopsis The heart’s electrical activity depends on sodium channels (NaV1.5) and dysfunction can cause dangerous arrhythmias. Researchers studied how NAD+ precursors nicotinamide riboside (NR) and...

Gut Bacteria Support NAD+ Production: Preclinical Findings

Synopsis Nicotinamide adenine dinucleotide (NAD+) is essential for hundreds of cellular processes, including metabolism, DNA repair, and aging. How environmental factors affect NAD+ metabolism is ...

Neonatal Nicotinamide Riboside and Resveratrol Epigenetically Program White Fat Browning: Preclinical Findings

Synopsis Giving newborn male mice resveratrol (RSV) or nicotinamide riboside (NR) can “program” their white fat to develop brown fat-like features (WAT browning) and improve metabolism later in li...