Article: Nicotinamide Riboside Reduces Brain Inflammation, Protects Muscle Health, and Enhances Weight Loss in Obesity: Preclinical Findings

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Metabolic Health Muscle Health Obesity Preclinical

Nicotinamide Riboside Reduces Brain Inflammation, Protects Muscle Health, and Enhances Weight Loss in Obesity: Preclinical Findings

Synopsis

Obesity treatments like calorie restriction (CR) often cause muscle loss and increase brain inflammation, which can interfere with weight control. In this study, obese rats were given CR, nicotinamide riboside (NR), or both. CR alone reduced muscle weight and increased hypothalamic inflammation. NR supplementation improved muscle mass, promoted weight loss, and reversed CR-induced inflammation in the brain. These results suggest that NR may help protect muscle and reduce neuroinflammation during weight loss, making it a promising supplement for obesity management.

Journal

Frontiers in Nutrition

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